ASAP2 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 - human protein (Function)
 
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ASAP2 »  Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
 
Protein also known as:  Paxillin-associated protein with ARF GAP activity 3 (PAG3).
Gene name:  ASAP2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 2
GENE REF ISO

Function

 show evidences
Overview 
Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.  
4
  • UniProtKB
GO molecular function 
ARF GTPase activator activitydefinition[GO:0008060] silver  
1
  • InterPro 2 GO
Enzyme activator activitydefinition[GO:0008047]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • GOC
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • InterPro 2 GO
  • UniProtKB KW
Regulation of ARF GTPase activitydefinition[GO:0032312] silver  
1
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocytosis  hsa04144+8853  
Fc gamma R-mediated phagocytosis  hsa04666+8853  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DDEF2
GenomeRNAi: 8853
PRO: PR:O43150