ARHGAP6 - Rho GTPase-activating protein 6 - human protein (Function)
 
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ARHGAP6 »  Rho GTPase-activating protein 6
 
Protein also known as:  Rho-type GTPase-activating protein RhoGAPX-1.
Gene name:  ARHGAP6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 5
GENE REF ISO

Function

 show evidences
Overview 
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.  
1
  • CuratedUniProtKB
GO molecular function 
Isoform  Iso 4   Phospholipase activator activitydefinition[GO:0016004]  
1
  • IDABHF-UCL
Isoform  Iso 4   Phospholipase bindingdefinition[GO:0043274]  
1
  • IPIBHF-UCL
Rho GTPase activator activitydefinition[GO:0005100]  
1
  • ISSBHF-UCL
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • TASPINC
GO biological process 
Actin filament polymerizationdefinition[GO:0030041]  
1
  • NASUniProtKB
Isoform  Iso 4   Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • IDABHF-UCL
Focal adhesion assemblydefinition[GO:0048041] silver  
  • IEAOrtholog Compara
Negative regulation of focal adhesion assemblydefinition[GO:0051895]  
1
  • IMPBHF-UCL
Negative regulation of stress fiber assemblydefinition[GO:0051497]  
1
  • IMPBHF-UCL
Isoform  Iso 4   Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • IDABHF-UCL
Positive regulation of Rho GTPase activitydefinition[GO:0032321] silver  
  • IEAOrtholog Compara
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
Regulation of GTPase activitydefinition[GO:0043087]  
1
  • ISSBHF-UCL
Rho protein signal transductiondefinition[GO:0007266]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Rho GTPase cycle  REACT_11051  
Note 
ARHGAP6 gene undergoes X inactivation.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 395
PRO: PR:O43182