ADAM12 - Disintegrin and metalloproteinase domain-containing protein 12 - human protein (Function)
 
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ADAM12 »  Disintegrin and metalloproteinase domain-containing protein 12   [ EC 3.4.24.- ]  (ADAM 12)
 
Protein also known as:  Meltrin-alpha.
Gene name:  ADAM12
Entry whose protein(s) existence is based on evidence at protein level
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1 122 4
GENE REF ISO

Function

 show evidences
Overview 
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
1
  • TASPINC
Isoform  Iso 2   Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
SH3 domain bindingdefinition[GO:0017124]  
1
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Myoblast fusiondefinition[GO:0007520]  
1
  • TASPINC
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAM12
GenomeRNAi: 8038
PRO: PR:O43184