CRX - Cone-rod homeobox protein - human protein (Function)
 
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Protein
Gene
References

 
CRX »  Cone-rod homeobox protein
 
Gene name:  CRX
Family name: Paired homeobox
Entry whose protein(s) existence is based on evidence at protein level
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1 46 1
GENE REF ISO

Function

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Overview 
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Leucine zipper domain bindingdefinition[GO:0043522]  
1
  • IPIUniProtKB
Nuclear hormone receptor bindingdefinition[GO:0035257]  
  • ISSOrtholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • ISSOrtholog Curator
GO biological process 
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Organ morphogenesisdefinition[GO:0009887]  
1
  • TASPINC
Positive regulation of photoreceptor cell differentiationdefinition[GO:0046534] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Response to stimulusdefinition[GO:0050896]  
  • IEAUniProtKB KW
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Sensory transduction  definition   [KW-0716]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Vision  definition   [KW-0844]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CRX_(gene)
GenomeRNAi: 1406
PRO: PR:O43186