IRAK2 - Interleukin-1 receptor-associated kinase-like 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
IRAK2 »  Interleukin-1 receptor-associated kinase-like 2  (IRAK-2)
 
Gene name:  IRAK2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 1
GENE REF ISO

Function

 show evidences
Overview 
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • BHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • RefGenome
GO biological process 
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249]  
1
  • PINC
Inflammatory responsedefinition[GO:0006954]  
1
  • PINC
Interleukin-1-mediated signaling pathwaydefinition[GO:0070498]  
1
  • BHF-UCL
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663] silver  
1
  • Ortholog Compara
MyD88-dependent toll-like receptor signaling pathwaydefinition[GO:0002755]  
1
  • BHF-UCL
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • BHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • BHF-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cytokine-mediated signaling pathwaydefinition[GO:0001959]  
1
  • BHF-UCL
Response to interleukin-1definition[GO:0070555]  
1
  • BHF-UCL
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+3656  
Neurotrophin signaling pathway  hsa04722+3656  
Tuberculosis  hsa05152+3656  
According to Reactome, this protein belongs to the following pathways:
activated TAK1 mediates p38 MAPK activation  R-HSA-450302  
Interleukin-1 signaling  R-HSA-446652  
IRAK2 mediated activation of TAK1 complex  R-HSA-937042  
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation  R-HSA-975163  
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1  R-HSA-450321  
MyD88 cascade initiated on plasma membrane  R-HSA-975871  
MyD88 dependent cascade initiated on endosome  R-HSA-975155  
MyD88:Mal cascade initiated on plasma membrane  R-HSA-166058  
NOD1/2 Signaling Pathway  R-HSA-168638  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  R-HSA-445989  
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation  R-HSA-975138  
Caution 
Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRAK2
GenomeRNAi: 3656
PRO: PR:O43187