IRAK2 - Interleukin-1 receptor-associated kinase-like 2 - human protein (Function)
 
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IRAK2 »  Interleukin-1 receptor-associated kinase-like 2  (IRAK-2)
 
Gene name:  IRAK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Protein kinase activitydefinition[GO:0004672] silver  
  • IEAInterPro 2 GO
GO biological process 
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Interleukin-1-mediated signaling pathwaydefinition[GO:0070498]  
1
  • IMPBHF-UCL
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663] silver  
  • IEAOrtholog Compara
MyD88-dependent toll-like receptor signaling pathwaydefinition[GO:0002755]  
1
  • TASBHF-UCL
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • IMPBHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPBHF-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of cytokine-mediated signaling pathwaydefinition[GO:0001959]  
1
  • IMPBHF-UCL
Response to interleukin-1definition[GO:0070555]  
1
  • IMPBHF-UCL
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+3656  
Neurotrophin signaling pathway  hsa04722+3656  
Tuberculosis  hsa05152+3656  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
Caution 
Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRAK2
GenomeRNAi: 3656
PRO: PR:O43187