GPAA1 - Glycosylphosphatidylinositol anchor attachment 1 protein - human protein (Function)
 
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Protein
Gene
References

 
GPAA1 »  Glycosylphosphatidylinositol anchor attachment 1 protein  (GPI anchor attachment protein 1)
 
Protein also known as:  GAA1 protein homolog.
Gene name:  GPAA1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 2
GENE REF ISO

Function

 show evidences
Overview 
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.  
1
  • CuratedUniProtKB
GO molecular function 
Contributes to GPI anchor bindingdefinition[GO:0034235]  
1
  • IMPUniProtKB
Contributes to GPI-anchor transamidase activitydefinition[GO:0003923]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Tubulin bindingdefinition[GO:0015631]  
1
  • NASUniProtKB
GO biological process 
Attachment of GPI anchor to proteindefinition[GO:0016255]  
2
  • TASUniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • NASUniProtKB
Protein retention in ER lumendefinition[GO:0006621]  
1
  • NASUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis  hsa00563+8733  
Metabolic pathways  hsa01100+8733  
According to Reactome, this protein belongs to the following pathway:
Attachment of GPI anchor to uPAR  REACT_1830  
 

Keywords

Biological process 
GPI-anchor biosynthesis  definition   [KW-0337]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPAA1
GenomeRNAi: 8733
PRO: PR:O43292