ADCY6 - Adenylate cyclase type 6 - human protein (Function)
 
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ADCY6 »  Adenylate cyclase type 6   [ EC 4.6.1.1 ]
 
Protein also known as:  Ca(2+)-inhibitable adenylyl cyclase.
Gene name:  ADCY6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

 show evidences
Overview 
Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
1
  • IDABHF-UCL
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
  • ISSOrtholog Curator
GO biological process 
cAMP biosynthetic processdefinition[GO:0006171]  
1
  • IDABHF-UCL
Cellular response to catecholamine stimulusdefinition[GO:0071870]  
1
  • IDABHF-UCL
Cellular response to prostaglandin E stimulusdefinition[GO:0071380]  
1
  • IDABHF-UCL
Dopamine receptor signaling pathwaydefinition[GO:0007212]  
1
  • IDABHF-UCL
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation by RAF1 results in its activation.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+112  
Chemokine signaling pathway  hsa04062+112  
Cholinergic synapse  hsa04725+112  
Dilated cardiomyopathy  hsa05414+112  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+112  
GABAergic synapse  hsa04727+112  
Gap junction  hsa04540+112  
Gastric acid secretion  hsa04971+112  
Glutamatergic synapse  hsa04724+112  
GnRH signaling pathway  hsa04912+112  
HTLV-I infection  hsa05166+112  
Melanogenesis  hsa04916+112  
Oocyte meiosis  hsa04114+112  
Pancreatic secretion  hsa04972+112  
Progesterone-mediated oocyte maturation  hsa04914+112  
Purine metabolism  hsa00230+112  
Salivary secretion  hsa04970+112  
Taste transduction  hsa04742+112  
Vascular smooth muscle contraction  hsa04270+112  
Vasopressin-regulated water reabsorption  hsa04962+112  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY6
GenomeRNAi: 112
PRO: PR:O43306