ADCY6 - Adenylate cyclase type 6 - human protein (Function)
 
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Protein
Gene
References

 
ADCY6 »  Adenylate cyclase type 6   [ EC 4.6.1.1 ]
 
Protein also known as:  Ca(2+)-inhibitable adenylyl cyclase.
Gene name:  ADCY6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 2
GENE REF ISO

Function

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Overview 
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed17916776, PubMed17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).  
5
  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
2
  • BHF-UCL
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Calcium- and calmodulin-responsive adenylate cyclase activitydefinition[GO:0008294] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • Ortholog Curator
Scaffold protein bindingdefinition[GO:0097110] silver  
1
  • Ortholog Compara
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • UniProtKB
cAMP biosynthetic processdefinition[GO:0006171]  
2
  • BHF-UCL
  • UniProtKB
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • RefGenome
Cellular response to catecholamine stimulusdefinition[GO:0071870]  
1
  • BHF-UCL
Cellular response to forskolindefinition[GO:1904322]  
1
  • UniProtKB
Cellular response to prostaglandin E stimulusdefinition[GO:0071380]  
1
  • BHF-UCL
Cellular response to vasopressindefinition[GO:1904117]  
1
  • Ortholog Curator
Dopamine receptor signaling pathwaydefinition[GO:0007212]  
1
  • BHF-UCL
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
1
  • Ortholog Curator
Negative regulation of urine volumedefinition[GO:0035811]  
1
  • Ortholog Curator
Regulation of vasodilationdefinition[GO:0042312]  
1
  • UniProtKB
Renal water homeostasisdefinition[GO:0003091]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
3
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).  
3
  • UniProtKB
It is regulated in the following manner
Activated by forskolin (PubMed17916776, PubMed:17110384). Inhibited by calcium ions, already at micromolar concentrations (By similarity). Inhibited by adenosine, AMP and their analogs (By similarity). Activated by GNAS (PubMed:17110384). Is further activated by the complex formed by GNB1 and GNG2 (PubMed:17110384). Phosphorylation by RAF1 results in its activation (By similarity).  
5
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+112  
Chemokine signaling pathway  hsa04062+112  
Cholinergic synapse  hsa04725+112  
Dilated cardiomyopathy  hsa05414+112  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+112  
GABAergic synapse  hsa04727+112  
Gap junction  hsa04540+112  
Gastric acid secretion  hsa04971+112  
Glutamatergic synapse  hsa04724+112  
GnRH signaling pathway  hsa04912+112  
HTLV-I infection  hsa05166+112  
Melanogenesis  hsa04916+112  
Oocyte meiosis  hsa04114+112  
Pancreatic secretion  hsa04972+112  
Progesterone-mediated oocyte maturation  hsa04914+112  
Purine metabolism  hsa00230+112  
Salivary secretion  hsa04970+112  
Taste transduction  hsa04742+112  
Vascular smooth muscle contraction  hsa04270+112  
Vasopressin-regulated water reabsorption  hsa04962+112  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
Adrenaline,noradrenaline inhibits insulin secretion  R-HSA-400042  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADCY6
GenomeRNAi: 112
PRO: PR:O43306
Chemistry
GuidetoPHARMACOLOGY: 1283