ARHGEF9 - Rho guanine nucleotide exchange factor 9 - human protein (Function)
 
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ARHGEF9 »  Rho guanine nucleotide exchange factor 9
 
Protein also known as:  Rac/Cdc42 guanine nucleotide exchange factor 9.
Gene name:  ARHGEF9
Entry whose protein(s) existence is based on evidence at protein level
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1 39 3
GENE REF ISO

Function

 show evidences
Overview 
Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.  
2
  • UniProtKB
GO molecular function 
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
1
  • InterPro 2 GO
GO biological process 
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • UniProtKB KW
  • InterPro 2 GO
Regulation of Rho protein signal transductiondefinition[GO:0035023] silver  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  R-HSA-416482  
GABA A receptor activation  R-HSA-977441  
Ligand-gated ion channel transport  R-HSA-975298  
NRAGE signals death through JNK  R-HSA-193648  
Rho GTPase cycle  R-HSA-194840  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF9
GenomeRNAi: 23229
PRO: PR:O43307