AQP9 - Aquaporin-9 - human protein (Function)
 
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AQP9 »  Aquaporin-9  (AQP-9)
 
Protein also known as:  Small solute channel 1.
Gene name:  AQP9
Entry whose protein(s) existence is based on evidence at protein level
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1 47 1
GENE REF ISO

Function

 show evidences
Overview 
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.  
1
  • CuratedUniProtKB
GO molecular function 
Amine transmembrane transporter activitydefinition[GO:0005275]  
1
  • TASUniProtKB
Carboxylic acid transmembrane transporter activitydefinition[GO:0046943]  
1
  • TASUniProtKB
Polyol transmembrane transporter activitydefinition[GO:0015166]  
1
  • TASUniProtKB
Porin activitydefinition[GO:0015288]  
1
  • NASUniProtKB
Purine nucleobase transmembrane transporter activitydefinition[GO:0005345]  
1
  • IDAUniProtKB
Pyrimidine nucleobase transmembrane transporter activitydefinition[GO:0005350]  
1
  • IDAUniProtKB
Water channel activitydefinition[GO:0015250]  
1
  • IDAUniProtKB
Water transmembrane transporter activitydefinition[GO:0005372]  
1
  • TASUniProtKB
GO biological process 
Amine transportdefinition[GO:0015837]  
1
  • IDAUniProtKB
Canalicular bile acid transportdefinition[GO:0015722] silver  
  • IEAOrtholog Compara
Carboxylic acid transportdefinition[GO:0046942]  
1
  • TASUniProtKB
Cellular response to cAMPdefinition[GO:0071320]  
1
  • IEPUniProtKB
Excretiondefinition[GO:0007588]  
1
  • TASUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Metabolic processdefinition[GO:0008152]  
1
  • TASUniProtKB
Polyol transportdefinition[GO:0015791]  
1
  • IDAUniProtKB
Purine nucleobase transportdefinition[GO:0006863]  
1
  • IDAUniProtKB
Pyrimidine nucleobase transportdefinition[GO:0015855]  
1
  • IDAUniProtKB
Pyrimidine-containing compound transmembrane transportdefinition[GO:0072531]  
1
  • IDAGOC
Response to mercury iondefinition[GO:0046689]  
1
  • IDAUniProtKB
Response to organic substancedefinition[GO:0010033]  
1
  • IDAUniProtKB
Response to osmotic stressdefinition[GO:0006970]  
1
  • TASUniProtKB
Transportdefinition[GO:0006810]  
1
  • TASUniProtKB
Water homeostasisdefinition[GO:0030104]  
1
  • NASUniProtKB
Water transportdefinition[GO:0006833]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+366  
According to Reactome, this protein belongs to the following pathways:
Passive transport by Aquaporins  REACT_23826  
Transport of glycerol from adipocytes to the liver by Aquaporins  REACT_23809  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: AQP9
GenomeRNAi: 366
PRO: PR:O43315
Chemistry
GuidetoPHARMACOLOGY: 696