TBX1 - T-box transcription factor TBX1 - human protein (Function)
 
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TBX1 »  T-box transcription factor TBX1  (T-box protein 1)
 
Protein also known as:  Testis-specific T-box protein.
Gene name:  TBX1
Entry whose protein(s) existence is based on evidence at protein level
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1 40 3
GENE REF ISO

Function

 show evidences
Overview 
Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Isoform  C   DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Isoform  C   Protein dimerization activitydefinition[GO:0046983]  
1
  • TASUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Not  Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Anterior/posterior pattern specificationdefinition[GO:0009952]  
  • ISSOrtholog Curator
Aorta morphogenesisdefinition[GO:0035909]  
  • ISSOrtholog Curator
Artery morphogenesisdefinition[GO:0048844]  
  • ISSOrtholog Curator
Blood vessel developmentdefinition[GO:0001568]  
  • ISSOrtholog Curator
Blood vessel morphogenesisdefinition[GO:0048514]  
  • ISSOrtholog Curator
Blood vessel remodelingdefinition[GO:0001974] silver  
  • IEAOrtholog Compara
Cell fate specificationdefinition[GO:0001708]  
  • ISSOrtholog Curator
Cell proliferationdefinition[GO:0008283]  
  • ISSOrtholog Curator
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344]  
  • ISSOrtholog Curator
Cellular response to retinoic aciddefinition[GO:0071300]  
  • ISSOrtholog Curator
Cochlea morphogenesisdefinition[GO:0090103]  
  • ISSOrtholog Curator
Coronary artery morphogenesisdefinition[GO:0060982]  
  • ISSOrtholog Curator
Determination of left/right symmetrydefinition[GO:0007368]  
  • ISSOrtholog Curator
Ear morphogenesisdefinition[GO:0042471]  
  • ISSOrtholog Curator
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701]  
  • ISSOrtholog Curator
Isoform  C   Embryonic viscerocranium morphogenesisdefinition[GO:0048703]  
1
  • IMPUniProtKB
Enamel mineralizationdefinition[GO:0070166]  
  • ISSOrtholog Curator
Epithelial cell differentiationdefinition[GO:0030855]  
  • ISSOrtholog Curator
Face morphogenesisdefinition[GO:0060325]  
  • ISSOrtholog Curator
Isoform  C   Heart developmentdefinition[GO:0007507]  
1
  • IMPUniProtKB
Heart morphogenesisdefinition[GO:0003007]  
  • ISSOrtholog Curator
Inner ear morphogenesisdefinition[GO:0042472]  
  • ISSOrtholog Curator
Lymph vessel developmentdefinition[GO:0001945]  
  • ISSOrtholog Curator
Mesenchymal cell apoptotic processdefinition[GO:0097152]  
  • ISSOrtholog Curator
Mesoderm developmentdefinition[GO:0007498]  
  • ISSOrtholog Curator
Middle ear morphogenesisdefinition[GO:0042474]  
  • ISSOrtholog Curator
Muscle cell fate commitmentdefinition[GO:0042693]  
  • ISSOrtholog Curator
Muscle organ developmentdefinition[GO:0007517]  
  • ISSOrtholog Curator
Muscle organ morphogenesisdefinition[GO:0048644]  
  • ISSOrtholog Curator
Muscle tissue morphogenesisdefinition[GO:0060415]  
  • ISSOrtholog Curator
Negative regulation of cell differentiationdefinition[GO:0045596]  
  • ISSOrtholog Curator
Negative regulation of mesenchymal cell apoptotic processdefinition[GO:2001054]  
  • ISSOrtholog Curator
Neural crest cell migrationdefinition[GO:0001755]  
  • ISSOrtholog Curator
Odontogenesis of dentin-containing toothdefinition[GO:0042475]  
  • ISSOrtholog Curator
Otic vesicle morphogenesisdefinition[GO:0071600] silver  
  • IEAOrtholog Compara
Outer ear morphogenesisdefinition[GO:0042473]  
  • ISSOrtholog Curator
Outflow tract morphogenesisdefinition[GO:0003151]  
  • ISSOrtholog Curator
Outflow tract septum morphogenesisdefinition[GO:0003148]  
  • ISSOrtholog Curator
Isoform  C   Parathyroid gland developmentdefinition[GO:0060017]  
1
  • IMPUniProtKB
Pattern specification processdefinition[GO:0007389]  
  • ISSOrtholog Curator
Pharyngeal system developmentdefinition[GO:0060037]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
  • ISSOrtholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
  • ISSOrtholog Curator
Positive regulation of MAPK cascadedefinition[GO:0043410]  
  • ISSOrtholog Curator
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053]  
  • ISSOrtholog Curator
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
  • ISSOrtholog Curator
Positive regulation of secondary heart field cardioblast proliferationdefinition[GO:0072513] silver  
  • IEAOrtholog Compara
Positive regulation of tongue muscle cell differentiationdefinition[GO:2001037]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Regulation of organ morphogenesisdefinition[GO:2000027]  
  • ISSOrtholog Curator
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Retinoic acid receptor signaling pathwaydefinition[GO:0048384]  
  • ISSOrtholog Curator
Semicircular canal morphogenesisdefinition[GO:0048752]  
  • ISSOrtholog Curator
Sensory perception of sounddefinition[GO:0007605]  
  • ISSOrtholog Curator
Social behaviordefinition[GO:0035176]  
  • ISSOrtholog Curator
Isoform  C   Soft palate developmentdefinition[GO:0060023]  
1
  • IMPUniProtKB
Isoform  C   Thymus developmentdefinition[GO:0048538]  
1
  • IMPUniProtKB
Thyroid gland developmentdefinition[GO:0030878]  
  • ISSOrtholog Curator
Tongue morphogenesisdefinition[GO:0043587]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Vagus nerve morphogenesisdefinition[GO:0021644]  
  • ISSOrtholog Curator
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6899
PRO: PR:O43435