MBTPS2 - Membrane-bound transcription factor site-2 protease - human protein (Function)
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MBTPS2 »  Membrane-bound transcription factor site-2 protease   [ EC ]
Protein also known as:  Sterol regulatory element-binding proteins intramembrane protease (SREBPs intramembrane protease).
Gene name:  MBTPS2
Family name: Peptidase M50A
Entry whose protein(s) existence is based on evidence at protein level
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Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
GO biological process 
Cholesterol metabolic processdefinition[GO:0008203]  
  • IEAUniProtKB KW
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+51360  
According to Reactome, this protein belongs to the following pathways:
ATF6-alpha activates chaperones  REACT_18348  
Regulation of cholesterol biosynthesis by SREBP (SREBF)  REACT_147797  


Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 51360
PRO: PR:O43462