AKR7A2 - Aflatoxin B1 aldehyde reductase member 2 - human protein (Function)
 
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AKR7A2 »  Aflatoxin B1 aldehyde reductase member 2   [ EC 1.1.1.n11 ]
 
Protein also known as:  Succinic semialdehyde reductase (SSA reductase).
Gene name:  AKR7A2
Entry whose protein(s) existence is based on evidence at protein level
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1 24 1
GENE REF ISO

Function

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Overview 
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.  
2
  • CuratedUniProtKB
GO molecular function 
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032]  
1
  • TASPINC
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Phenanthrene-9,10-epoxide hydrolase activitydefinition[GO:0019119]  
1
  • IDAUniProtKB
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • TASPINC
Cellular aldehyde metabolic processdefinition[GO:0006081]  
1
  • TASPINC
Daunorubicin metabolic processdefinition[GO:0044597]  
1
  • IMPUniProtKB
Doxorubicin metabolic processdefinition[GO:0044598]  
1
  • IMPUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.-: 4-hydroxybutanoate + NADP(+) succinate semialdehyde + NADPH.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Metabolism of xenobiotics by cytochrome P450  hsa00980+8574  
 

Biophysicochemical properties

Kinetic parameters
KM 102 uM for 1,2-naphthoquinone
KM 20 uM for succinic semialdehyde
KM 8 uM for 9,10-phenanthrenequinone
KM 17 uM for 2-carboxybenzaldehyde

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O43488
Other
GeneWiki: AKR7A2
GenomeRNAi: 8574
PRO: PR:O43488