CACNA1G - Voltage-dependent T-type calcium channel subunit alpha-1G - human protein (Function)
 
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Protein
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References

 
CACNA1G »  Voltage-dependent T-type calcium channel subunit alpha-1G
 
Protein also known as:  Voltage-gated calcium channel subunit alpha Cav3.1.
Gene name:  CACNA1G
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.  
  • CuratedUniProtKB
GO molecular function 
Low voltage-gated calcium channel activitydefinition[GO:0008332]  
1
  • IDABHF-UCL
Scaffold protein bindingdefinition[GO:0097110]  
1
  • IPIBHF-UCL
GO biological process 
Calcium ion importdefinition[GO:0070509]  
1
  • IDABHF-UCL
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Positive regulation of calcium ion-dependent exocytosisdefinition[GO:0045956] silver  
  • IBARefGenome
Regulation of atrial cardiac muscle cell membrane depolarizationdefinition[GO:0060371] silver  
  • IEAOrtholog Compara
Regulation of heart ratedefinition[GO:0002027] silver  
  • IEAOrtholog Compara
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDABHF-UCL
Response to nickel cationdefinition[GO:0010045] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+8913  
MAPK signaling pathway  hsa04010+8913  
Type II diabetes mellitus  hsa04930+8913  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CACNA1G
GenomeRNAi: 8913
PRO: PR:O43497
Chemistry
GuidetoPHARMACOLOGY: 535