KCNQ3 - Potassium voltage-gated channel subfamily KQT member 3 - human protein (Function)
 
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KCNQ3 »  Potassium voltage-gated channel subfamily KQT member 3
 
Protein also known as:  Voltage-gated potassium channel subunit Kv7.3.
Gene name:  KCNQ3
Entry whose protein(s) existence is based on evidence at protein level
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1 63 2
GENE REF ISO

Function

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Overview 
Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.15.3  
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251] silver  
  • IBARefGenome
Potassium channel activitydefinition[GO:0005267]  
1
  • TASPINC
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • TASPINC
GO biological process 
Membrane hyperpolarizationdefinition[GO:0060081] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cholinergic synapse  hsa04725+3786  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Neuronal System  REACT_13685  
Note 
Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ3(mut) and KCNQ2 at the ratio of 1:1, or of KCNQ3(mut), KCNQ3(wt) and KCNQ2 at the ratio of 1:1:2, to mimic the situation in a heterozygous patient with BFNC2 disease.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KvLQT3
GenomeRNAi: 3786
PRO: PR:O43525
Chemistry
GuidetoPHARMACOLOGY: 562