KCNQ2 - Potassium voltage-gated channel subfamily KQT member 2 - human protein (Function)
 
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KCNQ2 »  Potassium voltage-gated channel subfamily KQT member 2
 
Gene name:  KCNQ2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 101 6
GENE REF ISO

Function

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Overview 
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.15.2  
GO molecular function 
Ankyrin bindingdefinition[GO:0030506]  
1
  • IPIBHF-UCL
Delayed rectifier potassium channel activitydefinition[GO:0005251] silver  
  • IBARefGenome
Potassium channel activitydefinition[GO:0005267]  
1
  • TASPINC
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • TASPINC
GO biological process 
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Potassium ion transmembrane transportdefinition[GO:0071805]  
  • IEAUniProtKB KW
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Transmission of nerve impulsedefinition[GO:0019226] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cholinergic synapse  hsa04725+3785  
According to Reactome, this protein belongs to the following pathways:
Interaction between L1 and Ankyrins  REACT_22266  
Voltage gated Potassium channels  REACT_75770  
Note 
Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to provide cues for proliferation rather than differentiation.  
  • CuratedUniProtKB
Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ2(mut) and KCNQ3 at the ratio of 1:1, or of KCNQ2(mut), KCNQ2(wt) and KCNQ3 at the ratio of 1:1:2, to mimic the situation in a heterozygous patient with BFNC1 disease.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KvLQT2
GenomeRNAi: 3785
PRO: PR:O43526
Chemistry
GuidetoPHARMACOLOGY: 561