SMAD6 - Mothers against decapentaplegic homolog 6 - human protein (Function)
 
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SMAD6 »  Mothers against decapentaplegic homolog 6
 
Gene name:  SMAD6
Family name: Dwarfin/SMAD
Entry whose protein(s) existence is based on evidence at protein level
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1 55 3
GENE REF ISO

Function

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Overview 
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.  
4
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
Co-SMAD bindingdefinition[GO:0070410]  
1
  • IPIBHF-UCL
I-SMAD bindingdefinition[GO:0070411]  
1
  • IPIBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
R-SMAD bindingdefinition[GO:0070412]  
2
  • IPIBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
Transforming growth factor beta receptor, inhibitory cytoplasmic mediator activitydefinition[GO:0030617]  
2
  • IMPBHF-UCL
Type I activin receptor bindingdefinition[GO:0070698]  
1
  • IDABHF-UCL
Type I transforming growth factor beta receptor bindingdefinition[GO:0034713]  
1
  • IDABHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIBHF-UCL
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
1
  • IDAUniProtKB
Cell-substrate adhesiondefinition[GO:0031589]  
1
  • IMPUniProtKB
Fat cell differentiationdefinition[GO:0045444]  
1
  • IDAUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • IMPBHF-UCL
Intracellular signal transductiondefinition[GO:0035556]  
2
  • IMPGOC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPBHF-UCL
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
1
  • IDABHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPBHF-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0060394]  
2
  • IMPBHF-UCL
Negative regulation of SMAD protein complex assemblydefinition[GO:0010991]  
1
  • IDABHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512]  
1
  • IMPBHF-UCL
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to laminar fluid shear stressdefinition[GO:0034616]  
1
  • IEPBHF-UCL
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179] silver  
  • IEAInterPro 2 GO
Ureteric bud developmentdefinition[GO:0001657] silver  
  • IEAOrtholog Compara
Zygotic specification of dorsal/ventral axisdefinition[GO:0007352]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocytosis  hsa04144+4091  
TGF-beta signaling pathway  hsa04350+4091  
According to Reactome, this protein belongs to the following pathway:
Signaling by BMP  REACT_12034  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links