XRCC3 - DNA repair protein XRCC3 - human protein (Function)
 
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XRCC3 »  DNA repair protein XRCC3
 
Protein also known as:  X-ray repair cross-complementing protein 3.
Gene name:  XRCC3
Family name: RecA » RAD51
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 152 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Contributes to crossover junction endodeoxyribonuclease activitydefinition[GO:0008821]  
2
  • IMPUniProtKB
DNA-dependent ATPase activitydefinition[GO:0008094] silver  
  • IEAInterPro 2 GO
Contributes to four-way junction DNA bindingdefinition[GO:0000400]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • TASPINC
DNA catabolic process, endonucleolyticdefinition[GO:0000737]  
2
  • IMPGOC
DNA recombinationdefinition[GO:0006310]  
1
  • TASPINC
DNA repairdefinition[GO:0006281]  
1
  • IGIBHF-UCL
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
1
  • IMPUniProtKB
Positive regulation of mitotic cell cycle spindle assembly checkpointdefinition[GO:0090267]  
1
  • IMPUniProtKB
Regulation of centrosome duplicationdefinition[GO:0010824]  
1
  • IMPUniProtKB
Resolution of mitotic recombination intermediatesdefinition[GO:0071140]  
1
  • IMPUniProtKB
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Homologous recombination  hsa03440+7517  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XRCC3
GenomeRNAi: 7517
PRO: PR:O43542