RGS14 - Regulator of G-protein signaling 14 - human protein (Function)
 
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RGS14 »  Regulator of G-protein signaling 14  (RGS14)
 
Gene name:  RGS14
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 4
GENE REF ISO

Function

 show evidences
Overview 
Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory.  
3
  • UniProtKB
GO molecular function 
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
1
  • Ortholog Compara
GDP-dissociation inhibitor activitydefinition[GO:0005092]  
1
  • UniProtKB
GTPase activating protein bindingdefinition[GO:0032794] silver  
1
  • Ortholog Compara
GTPase activator activitydefinition[GO:0005096]  
2
  • UniProtKB
  • RefGenome
Microtubule bindingdefinition[GO:0008017]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • Ortholog Curator
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • Ortholog Curator
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB
Chromosome segregationdefinition[GO:0007059]  
1
  • Ortholog Curator
Intracellular signal transductiondefinition[GO:0035556]  
3
  • Ortholog Curator
  • InterPro 2 GO
  • Ortholog Compara
Learningdefinition[GO:0007612]  
1
  • Ortholog Curator
Long-term memorydefinition[GO:0007616]  
1
  • Ortholog Curator
Long-term synaptic potentiationdefinition[GO:0060291]  
1
  • Ortholog Curator
Mitotic nuclear divisiondefinition[GO:0007067] silver  
1
  • Ortholog Compara
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
1
  • Ortholog Curator
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • Ortholog Curator
Negative regulation of synaptic plasticitydefinition[GO:0031914]  
1
  • Ortholog Curator
Nucleocytoplasmic transportdefinition[GO:0006913]  
1
  • Ortholog Curator
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
1
  • Ortholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
4
  • GOC
  • UniProtKB KW
  • RefGenome
Positive regulation of neurogenesisdefinition[GO:0050769]  
1
  • Ortholog Curator
Regulation of DNA-templated transcription in response to stressdefinition[GO:0043620]  
1
  • Ortholog Curator
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • PINC
Response to oxidative stressdefinition[GO:0006979]  
1
  • Ortholog Curator
Spindle organizationdefinition[GO:0007051]  
1
  • UniProtKB
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
1
  • InterPro 2 GO
Visual learningdefinition[GO:0008542]  
1
  • Ortholog Curator
Zygote asymmetric cell divisiondefinition[GO:0010070]  
1
  • Ortholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Molecular function 
GTPase activation  definition   [KW-0343]
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RGS14
GenomeRNAi: 10636
PRO: PR:O43566