RGS14 - Regulator of G-protein signaling 14 - human protein (Function)
 
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RGS14 »  Regulator of G-protein signaling 14  (RGS14)
 
Gene name:  RGS14
Entry whose protein(s) existence is based on evidence at protein level
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1 35 4
GENE REF ISO

Function

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Overview 
Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory.  
2
  • CuratedUniProtKB
GO molecular function 
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
  • IEAOrtholog Compara
GDP-dissociation inhibitor activitydefinition[GO:0005092]  
1
  • IDAUniProtKB
GTPase activating protein bindingdefinition[GO:0032794] silver  
  • IEAOrtholog Compara
GTPase activator activitydefinition[GO:0005096]  
1
  • IDAUniProtKB
  • IBARefGenome
Microtubule bindingdefinition[GO:0008017]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
  • ISSOrtholog Curator
Receptor signaling protein activitydefinition[GO:0005057]  
  • ISSOrtholog Curator
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • IMPUniProtKB
Chromosome segregationdefinition[GO:0007059]  
  • ISSOrtholog Curator
Intracellular signal transductiondefinition[GO:0035556]  
  • IEAInterPro 2 GO
  • ISSOrtholog Curator
  • IEAOrtholog Compara
Learningdefinition[GO:0007612]  
  • ISSOrtholog Curator
Long-term memorydefinition[GO:0007616]  
  • ISSOrtholog Curator
Long-term synaptic potentiationdefinition[GO:0060291]  
  • ISSOrtholog Curator
Mitotic nuclear divisiondefinition[GO:0007067] silver  
  • IEAOrtholog Compara
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
  • ISSOrtholog Curator
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
  • ISSOrtholog Curator
Negative regulation of synaptic plasticitydefinition[GO:0031914]  
  • ISSOrtholog Curator
Nucleocytoplasmic transportdefinition[GO:0006913]  
  • ISSOrtholog Curator
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
  • ISSOrtholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • IDAGOC
  • IEAUniProtKB KW
  • IBARefGenome
Positive regulation of neurogenesisdefinition[GO:0050769]  
  • ISSOrtholog Curator
Regulation of DNA-templated transcription in response to stressdefinition[GO:0043620]  
  • ISSOrtholog Curator
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • TASPINC
Response to oxidative stressdefinition[GO:0006979]  
  • ISSOrtholog Curator
Spindle organizationdefinition[GO:0007051]  
1
  • IMPUniProtKB
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Visual learningdefinition[GO:0008542]  
  • ISSOrtholog Curator
Zygote asymmetric cell divisiondefinition[GO:0010070]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Molecular function 
GTPase activation  definition   [KW-0343]
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RGS14
GenomeRNAi: 10636
PRO: PR:O43566