GALR2 - Galanin receptor type 2 - human protein (Function)
 
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GALR2 »  Galanin receptor type 2  (GALR-2)
 
Gene name:  GALR2
Entry whose protein(s) existence is based on evidence at protein level
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1 22 1
GENE REF ISO

Function

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Overview 
Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).  
1
  • CuratedUniProtKB
GO molecular function 
Galanin receptor activitydefinition[GO:0004966]  
1
  • IDAUniProtKB
Peptide hormone bindingdefinition[GO:0017046]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Digestiondefinition[GO:0007586]  
1
  • TASPINC
Feeding behaviordefinition[GO:0007631]  
1
  • TASPINC
Learning or memorydefinition[GO:0007611]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Negative regulation of adenylate cyclase activitydefinition[GO:0007194] silver  
  • IEAInterPro 2 GO
Neuron projection developmentdefinition[GO:0031175] silver  
  • IEAOrtholog Compara
Neuropeptide signaling pathwaydefinition[GO:0007218]  
2
  • IDAGOC
  • IEAInterPro 2 GO
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAInterPro 2 GO
Positive regulation of large conductance calcium-activated potassium channel activitydefinition[GO:1902608]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+8811  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Galanin_receptor_2
GenomeRNAi: 8811
PRO: PR:O43603
Chemistry
GuidetoPHARMACOLOGY: 244