SNAI2 - Zinc finger protein SNAI2 - human protein (Function)
 
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SNAI2 »  Zinc finger protein SNAI2
 
Gene name:  SNAI2
Entry whose protein(s) existence is based on evidence at protein level
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1 148 1
GENE REF ISO

Function

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Overview 
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.  
6
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
4
  • IDABHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
2
  • IDABHF-UCL
GO biological process 
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • IMPUniProtKB
Cartilage morphogenesisdefinition[GO:0060536] silver  
  • IEAOrtholog Compara
Cell migration involved in endocardial cushion formationdefinition[GO:0003273]  
  • ISSOrtholog Curator
Cellular response to epidermal growth factor stimulusdefinition[GO:0071364]  
1
  • IDABHF-UCL
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344] silver  
  • IEAOrtholog Compara
Cellular response to ionizing radiationdefinition[GO:0071479] silver  
  • IEAOrtholog Compara
Desmosome disassemblydefinition[GO:0035921]  
1
  • IMPBHF-UCL
Embryo developmentdefinition[GO:0009790] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
2
  • IMPBHF-UCL
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198]  
  • ISSOrtholog Curator
Epithelium developmentdefinition[GO:0060429]  
1
  • ISSBHF-UCL
Negative regulation of anoikisdefinition[GO:2000811]  
1
  • IMPBHF-UCL
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
2
  • IMPBHF-UCL
Negative regulation of catenin import into nucleusdefinition[GO:0035414]  
1
  • IDABHF-UCL
Negative regulation of cell adhesion involved in substrate-bound cell migrationdefinition[GO:0006933] silver  
  • IEAOrtholog Compara
Negative regulation of cell adhesion mediated by integrindefinition[GO:0033629]  
1
  • ICBHF-UCL
Negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoterdefinition[GO:1900387]  
3
  • IMPBHF-UCL
Negative regulation of chondrocyte differentiationdefinition[GO:0032331]  
1
  • IMPBHF-UCL
Negative regulation of DNA damage response, signal transduction by p53 class mediatordefinition[GO:0043518]  
1
  • IMPBHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • ISSBHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902230]  
1
  • IMPBHF-UCL
Negative regulation of keratinocyte proliferationdefinition[GO:0010839]  
1
  • IDABHF-UCL
Negative regulation of stem cell proliferationdefinition[GO:2000647] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
3
  • IMPBHF-UCL
Negative regulation of vitamin D biosynthetic processdefinition[GO:0010957]  
2
  • IDABHF-UCL
Negative regulation of vitamin D receptor signaling pathwaydefinition[GO:0070563]  
1
  • IDABHF-UCL
Neural crest cell developmentdefinition[GO:0014032]  
1
  • IMPBHF-UCL
Notch signaling pathwaydefinition[GO:0007219]  
1
  • IMPBHF-UCL
Osteoblast differentiationdefinition[GO:0001649]  
1
  • IEPUniProtKB
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Pigmentationdefinition[GO:0043473]  
1
  • IMPBHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPBHF-UCL
Positive regulation of fat cell differentiationdefinition[GO:0045600] silver  
  • IEAOrtholog Compara
Positive regulation of histone acetylationdefinition[GO:0035066] silver  
  • IEAOrtholog Compara
Regulation of branching involved in salivary gland morphogenesisdefinition[GO:0060693] silver  
  • IEAOrtholog Compara
Regulation of chemokine productiondefinition[GO:0032642]  
1
  • IMPBHF-UCL
Regulation of osteoblast differentiationdefinition[GO:0045667]  
2
  • IMPBHF-UCL
Regulation of tight junction assemblydefinition[GO:2000810]  
1
  • IMPBHF-UCL
Sensory perception of sounddefinition[GO:0007605]  
1
  • IMPBHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
  • IEAOrtholog Compara
White fat cell differentiationdefinition[GO:0050872] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SNAI2
GenomeRNAi: 6591
PRO: PR:O43623