SNAI2 - Zinc finger protein SNAI2 - human protein (Sequence)
 
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SNAI2 »  Zinc finger protein SNAI2
 
Protein also known as:  Neural crest transcription factor Slug.
Gene name:  SNAI2
Entry whose protein(s) existence is based on evidence at protein level
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1 139 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   268 aaMass: 29986 Da,  pI: 9.01
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS GAYSPITVWT TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS GSESPISDEE ERLQSKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH CDAQSRKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK YQCKNCSKTF SRMSLLHKHE ESGCCVAH

Sequence

 show evidences
Domain 
Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.  
  • CuratedUniProtKB
PTM 
GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Repeat  definition   [KW-0677]
Zinc-finger  definition   [KW-0863]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 3.30.160.60
InterPro: IPR015880 [ Znf C2H2-like ]
InterPro: IPR013087 [ Znf C2H2/integrase DNA-bd ]
InterPro: IPR007087 [ Znf C2H2 ]
Pfam: PF00096 [ zf-C2H2 ]
PROSITE: PS50157 [ ZINC FINGER C2H2 2 ]
PROSITE: PS00028 [ ZINC FINGER C2H2 1 ]
SMART: SM00355 [ ZnF C2H2 ]
Genome annotation databases
Ensembl: Transcript: ENST00000020945;  Protein: ENSP00000020945;  Gene: ENSG00000019549.
Ensembl: Transcript: ENST00000396822;  Protein: ENSP00000380034;  Gene: ENSG00000019549.
KEGG: hsa:6591
UCSC: uc003xqp.3
Organism-specific databases
MGI: MGI:1096393 [ Snai2 ]
PTM databases
PhosphoSite: O43623
Phylogenomic databases
eggNOG: COG5048
HOGENOM: HOG000261665
HOVERGEN: HBG007477
InParanoid: O43623
KO: K05706
OMA: EDEQMLP
OrthoDB: EOG7P2XSG
PhylomeDB: O43623
Sequence databases
CCDS: CCDS6146.1 [ O43623-1 ]
EMBL: mRNA:  BC014890 . Translation:  AAH14890.1 .
EMBL: mRNA:  AK223368 . Translation:  BAD97088.1 .
EMBL: Genomic DNA:  CH471068 . Translation:  EAW86700.1 .
EMBL: Genomic DNA:  AF042001 . Translation:  AAC34288.1 .
EMBL: mRNA:  BC015895 . Translation:  AAH15895.1 .
EMBL: Genomic DNA:  AF084243 . Translation:  AAD55240.1 .
EMBL: mRNA:  AK312661 . Translation:  BAG35543.1 .
IPI: IPI00013394
RefSeq: Protein:  NP_003059.1. Nucleotide sequence:  NM_003068.4.
UniProtKB: O43623
Protocols and materials databases
DNASU: 6591