NCK2 - Cytoplasmic protein NCK2 - human protein (Function)
 
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NCK2 »  Cytoplasmic protein NCK2
 
Protein also known as:  Growth factor receptor-bound protein 4.
Gene name:  NCK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.  
3
  • UniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • UniProtKB
Scaffold protein bindingdefinition[GO:0097110] silver  
1
  • Ortholog Compara
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • ParkinsonsUK-UCL
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
1
  • Ortholog Compara
Cell migrationdefinition[GO:0016477] silver  
1
  • Ortholog Compara
Dendritic spine developmentdefinition[GO:0060996] silver  
1
  • Ortholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • PINC
Immunological synapse formationdefinition[GO:0001771] silver  
1
  • Ortholog Compara
Lamellipodium assemblydefinition[GO:0030032] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylationdefinition[GO:1903912]  
1
  • ParkinsonsUK-UCL
Negative regulation of peptidyl-serine phosphorylationdefinition[GO:0033137]  
1
  • ParkinsonsUK-UCL
Negative regulation of PERK-mediated unfolded protein responsedefinition[GO:1903898] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990441] silver  
1
  • Ortholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • UniProtKB
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902237] silver  
1
  • Ortholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Positive regulation of translation in response to endoplasmic reticulum stressdefinition[GO:0036493] silver  
1
  • Ortholog Compara
Regulation of epidermal growth factor-activated receptor activitydefinition[GO:0007176]  
1
  • PINC
Signal complex assemblydefinition[GO:0007172]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
T cell activationdefinition[GO:0042110]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+8440  
ErbB signaling pathway  hsa04012+8440  
Pathogenic Escherichia coli infection  hsa05130+8440  
T cell receptor signaling pathway  hsa04660+8440  
According to Reactome, this protein belongs to the following pathways:
Activation of Rac  R-HSA-428540  
Downstream signal transduction  R-HSA-186763  
Ephrin signaling  R-HSA-3928664  
Nephrin interactions  R-HSA-373753  
VEGFA-VEGFR2 Pathway  R-HSA-4420097  
 

Keywords

Biological process 
Translation regulation  definition   [KW-0810]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NCK2
GenomeRNAi: 8440
PRO: PR:O43639