NCK2 - Cytoplasmic protein NCK2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
NCK2 »  Cytoplasmic protein NCK2
 
Protein also known as:  Growth factor receptor-bound protein 4.
Gene name:  NCK2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 54 1
GENE REF ISO

Function

 show evidences
Overview 
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.  
2
  • CuratedUniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • NASUniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
  • IEAOrtholog Compara
Cell migrationdefinition[GO:0016477] silver  
  • IEAOrtholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • TASPINC
Lamellipodium assemblydefinition[GO:0030032] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • IMPUniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Regulation of epidermal growth factor-activated receptor activitydefinition[GO:0007176]  
1
  • TASPINC
Regulation of translationdefinition[GO:0006417]  
  • IEAUniProtKB KW
Signal complex assemblydefinition[GO:0007172]  
1
  • NASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
T cell activationdefinition[GO:0042110]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+8440  
ErbB signaling pathway  hsa04012+8440  
Pathogenic Escherichia coli infection  hsa05130+8440  
T cell receptor signaling pathway  hsa04660+8440  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Translation regulation  definition   [KW-0810]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NCK2
GenomeRNAi: 8440
PRO: PR:O43639