RGS10 - Regulator of G-protein signaling 10 - human protein (Function)
 
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RGS10 »  Regulator of G-protein signaling 10  (RGS10)
 
Gene name:  RGS10
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.  
  • CuratedUniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096] silver  
  • IBARefGenome
GO biological process 
Positive regulation of GTPase activitydefinition[GO:0043547] silver  
  • IBARefGenome
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RGS10
GenomeRNAi: 6001
PRO: PR:O43665