ASNA1 - ATPase ASNA1 - human protein (Function)
 
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Protein
Gene
References

 
ASNA1 »  ATPase ASNA1   [ EC 3.6.-.- ]
 
Protein also known as:  Transmembrane domain recognition complex 40 kDa ATPase subunit.
Gene name:  ASNA1
Family name: ArsA ATPase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 1
GENE REF ISO

Function

 show evidences
Overview 
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.  
4
  • UniProtKB
  • HAMAP-Rule
According to TCDB this is a transporter from family:
the tms recognition/insertion complex (trc) family  3.A.19.1.1  
GO molecular function 
Arsenite transmembrane transporter activitydefinition[GO:0015105]  
1
  • PINC
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB Annot
ATPase activitydefinition[GO:0016887] silver  
1
  • InterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Transporter activitydefinition[GO:0005215]  
1
  • PINC
GO biological process 
Inorganic anion transportdefinition[GO:0015698]  
1
  • GOC
Protein insertion into ER membranedefinition[GO:0045048]  
1
  • UniProtKB Annot
Transportdefinition[GO:0006810]  
1
  • PINC
Enzymatic activity 
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 0.22 mM for ATP
Vmax 16.6 nmol/min/mg enzyme for ATP

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASNA1
GenomeRNAi: 439
PRO: PR:O43681