BUB1 - Mitotic checkpoint serine/threonine-protein kinase BUB1 - human protein (Function)
 
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BUB1 »  Mitotic checkpoint serine/threonine-protein kinase BUB1   [ EC 2.7.11.1 ]
 
Protein also known as:  BUB1A.
Gene name:  BUB1
Entry whose protein(s) existence is based on evidence at protein level
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1 95 3
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.  
7
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Chromosome segregationdefinition[GO:0007059] silver  
  • IEAOrtholog Compara
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • TASPINC
Mitotic spindle assembly checkpointdefinition[GO:0007094]  
1
  • TASPINC
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244] silver  
  • IEAOrtholog Compara
Regulation of chromosome segregationdefinition[GO:0051983]  
1
  • IMPUniProtKB
Regulation of sister chromatid cohesiondefinition[GO:0007063]  
1
  • IDAUniProtKB
Spindle assembly checkpointdefinition[GO:0071173]  
3
  • IMPUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Autophosphorylated when the cells enters mitosis.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+699  
Oocyte meiosis  hsa04114+699  
Progesterone-mediated oocyte maturation  hsa04914+699  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Chromosome partition  definition   [KW-0159]
Host-virus interaction  definition   [KW-0945]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BUB1
GenomeRNAi: 699
PRO: PR:O43683