GSTZ1 - Maleylacetoacetate isomerase - human protein (Function)
 
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GSTZ1 »  Maleylacetoacetate isomerase   [ EC 5.2.1.2 ]  (MAAI)
 
Protein also known as:  Glutathione S-transferase zeta 1 [EC 2.5.1.18].
Gene name:  GSTZ1
Family name: GST » Zeta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.  
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  • CuratedUniProtKB
GO molecular function 
Glutathione peroxidase activitydefinition[GO:0004602]  
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  • TASPINC
Glutathione transferase activitydefinition[GO:0004364]  
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  • IDAUniProtKB
Maleylacetoacetate isomerase activitydefinition[GO:0016034]  
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  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
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  • IPIUniProtKB
GO biological process 
Glutathione metabolic processdefinition[GO:0006749]  
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  • IDAUniProtKB
L-phenylalanine catabolic processdefinition[GO:0006559]  
  • IEAUniPathway
Oxidation-reduction processdefinition[GO:0055114]  
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  • TASGOC
Tyrosine catabolic processdefinition[GO:0006572]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 5.2.1.2: 4-maleylacetoacetate 4-fumarylacetoacetate.  
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  • CuratedUniProtKB
EC 2.5.1.18: RX + glutathione HX + R-S-glutathione.  
1
  • CuratedUniProtKB
It requires the following cofactor
Glutathione. Required for the MAAI activity.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - cytochrome P450  hsa00982+2954  
Glutathione metabolism  hsa00480+2954  
Metabolic pathways  hsa01100+2954  
Metabolism of xenobiotics by cytochrome P450  hsa00980+2954  
Tyrosine metabolism  hsa00350+2954  
According to Reactome, this protein belongs to the following pathways:
Glutathione conjugation  REACT_6926  
Phenylalanine and tyrosine catabolism  REACT_1786  
 
More information is available from:
 

Keywords

Biological process 
Phenylalanine catabolism  definition   [KW-0585]
Tyrosine catabolism  definition   [KW-0828]
Molecular function 
Isomerase  definition   [KW-0413]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GSTZ1
GenomeRNAi: 2954
PRO: PR:O43708