AP1G1 - AP-1 complex subunit gamma-1 - human protein (Function)
 
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Protein
Gene
References

 
AP1G1 »  AP-1 complex subunit gamma-1
 
Protein also known as:  Clathrin assembly protein complex 1 gamma-1 large chain.
Gene name:  AP1G1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 2
GENE REF ISO

Function

 show evidences
Overview 
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.  
  • CuratedUniProtKB
GO molecular function 
GTP-dependent protein bindingdefinition[GO:0030742]  
1
  • IPIBHF-UCL
Kinesin bindingdefinition[GO:0019894]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Protein transporter activitydefinition[GO:0008565] silver  
  • IEAInterPro 2 GO
Rab GTPase bindingdefinition[GO:0017137]  
1
  • IPIBHF-UCL
Transporter activitydefinition[GO:0005215]  
2
  • TASPINC
GO biological process 
Endosome to melanosome transportdefinition[GO:0035646]  
1
  • IMPBHF-UCL
Golgi to lysosome transportdefinition[GO:0090160]  
1
  • IMPUniProtKB
Intracellular protein transportdefinition[GO:0006886] silver  
  • IEAInterPro 2 GO
Melanosome organizationdefinition[GO:0032438]  
1
  • ICBHF-UCL
Positive regulation of natural killer cell degranulationdefinition[GO:0043323]  
1
  • IMPUniProtKB
Positive regulation of natural killer cell mediated cytotoxicitydefinition[GO:0045954]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+164  
According to Reactome, this protein belongs to the following pathways:
Golgi Associated Vesicle Biogenesis  REACT_19400  
Lysosome Vesicle Biogenesis  REACT_19287  
MHC class II antigen presentation  REACT_121399  
Nef mediated downregulation of MHC class I complex cell surface expression  REACT_11103  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AP1G1
GenomeRNAi: 164
PRO: PR:O43747