LIAS - Lipoyl synthase, mitochondrial - human protein (Function)
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View

LIAS »  Lipoyl synthase, mitochondrial   [ EC ]
Protein also known as:  Lipoic acid synthase.
Gene name:  LIAS
Family name: Radical SAM » Lipoyl synthase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 13 3


 show evidences
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity).  
  • CuratedUniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • IEAUniProtKB Annot
Lipoate synthase activitydefinition[GO:0016992]  
  • ISSOrtholog Curator
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
  • ISSOrtholog Curator
Lipoate biosynthetic processdefinition[GO:0009107]  
  • ISSOrtholog Curator
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Protein lipoylationdefinition[GO:0009249]  
  • IEAUniProtKB Annot
Response to lipopolysaccharidedefinition[GO:0032496]  
  • ISSOrtholog Curator
Response to oxidative stressdefinition[GO:0006979]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Lipoic acid metabolism  hsa00785+11019  
Metabolic pathways  hsa01100+11019  


Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 11019
PRO: PR:O43766