LIAS - Lipoyl synthase, mitochondrial - human protein (Function)
 
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LIAS »  Lipoyl synthase, mitochondrial   [ EC 2.8.1.8 ]
 
Protein also known as:  Lipoic acid synthase.
Gene name:  LIAS
Family name: Radical SAM » Lipoyl synthase
Entry whose protein(s) existence is based on evidence at protein level
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1 12 2
GENE REF ISO

Function

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Overview 
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity).  
  • CuratedUniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • IEAUniProtKB KW
Lipoate synthase activitydefinition[GO:0016992]  
  • ISSOrtholog Curator
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
  • ISSOrtholog Curator
Lipoate biosynthetic processdefinition[GO:0009107]  
  • ISSOrtholog Curator
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496]  
  • ISSOrtholog Curator
Response to oxidative stressdefinition[GO:0006979]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.8.1.8: Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Lipoic acid metabolism  hsa00785+11019  
Metabolic pathways  hsa01100+11019  
 

Keywords

Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 11019
PRO: PR:O43766