DYRK3 - Dual specificity tyrosine-phosphorylation-regulated kinase 3 - human protein (Function)
 
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DYRK3 »  Dual specificity tyrosine-phosphorylation-regulated kinase 3   [ EC 2.7.12.1 ]
 
Protein also known as:  Regulatory erythroid kinase (REDK).
Gene name:  DYRK3
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 27 2
GENE REF ISO

Function

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Overview 
Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein kinase activitydefinition[GO:0004672]  
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  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
  • IEAEC 2 GO
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • IEAUniProtKB KW
GO biological process 
Erythrocyte differentiationdefinition[GO:0030218]  
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  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
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  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by harmine, leucettamine B and leucettine L41.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DYRK3
GenomeRNAi: 8444
PRO: PR:O43781
Chemistry
GuidetoPHARMACOLOGY: 2012