SLC25A17 - Peroxisomal membrane protein PMP34 - human protein (Function)
 
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Protein
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SLC25A17 »  Peroxisomal membrane protein PMP34
 
Protein also known as:  34 kDa peroxisomal membrane protein.
Gene name:  SLC25A17
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the mitochondrial carrier (mc) family  2.A.29.20.1  
GO molecular function 
ADP transmembrane transporter activitydefinition[GO:0015217]  
1
  • IDAUniProtKB
AMP transmembrane transporter activitydefinition[GO:0080122]  
1
  • IDAUniProtKB
ATP transmembrane transporter activitydefinition[GO:0005347]  
1
  • IGIBHF-UCL
Chaperone bindingdefinition[GO:0051087]  
1
  • IPIBHF-UCL
Coenzyme A transmembrane transporter activitydefinition[GO:0015228]  
1
  • IDAUniProtKB
FAD transmembrane transporter activitydefinition[GO:0015230]  
1
  • IDAUniProtKB
FMN transmembrane transporter activitydefinition[GO:0044610]  
1
  • IDAUniProtKB
NAD transporter activitydefinition[GO:0051724]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
ADP transportdefinition[GO:0015866]  
1
  • IDAGOC
AMP transportdefinition[GO:0080121]  
1
  • IDAGOC
ATP transportdefinition[GO:0015867]  
1
  • IGIBHF-UCL
Coenzyme A transmembrane transportdefinition[GO:0035349]  
1
  • IDAGOC
FAD transmembrane transportdefinition[GO:0035350]  
1
  • IDAGOC
Fatty acid beta-oxidationdefinition[GO:0006635]  
1
  • IGIBHF-UCL
Fatty acid transportdefinition[GO:0015908]  
1
  • IGIBHF-UCL
NAD transportdefinition[GO:0043132]  
1
  • IDAGOC
Nucleotide transmembrane transportdefinition[GO:1901679]  
1
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Peroxisome  hsa04146+10478  
According to Reactome, this protein belongs to the following pathway:
Alpha-oxidation of phytanate  REACT_17003  
Caution 
Was first identified as a peroxisomal ATP transporter (PubMed12445829). However, later experiments showed that it acts as a peroxisomal transporter for multiple cofactors (PubMed22185573).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC25A17
GenomeRNAi: 10478
PRO: PR:O43808