SLC37A4 - Glucose-6-phosphate translocase - human protein (Function)
 
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Protein
Gene
References

 
SLC37A4 »  Glucose-6-phosphate translocase
 
Protein also known as:  Transformation-related gene 19 protein (TRG-19).
Gene name:  SLC37A4
Family name: Major facilitator » SLC37A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.4.5  
GO molecular function 
Glucose-6-phosphate transmembrane transporter activitydefinition[GO:0015152]  
2
  • IMPUniProtKB
Transporter activitydefinition[GO:0005215]  
1
  • NASUniProtKB
GO biological process 
Glucose homeostasisdefinition[GO:0042593]  
1
  • IDAUniProtKB
Glucose metabolic processdefinition[GO:0006006]  
1
  • NASUniProtKB
Glucose-6-phosphate transportdefinition[GO:0015760]  
2
  • IMPUniProtKB
Transportdefinition[GO:0006810]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Carbohydrate digestion and absorption  hsa04973+2542  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Sugar transport  definition   [KW-0762]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC37A4
GenomeRNAi: 2542
PRO: PR:O43826