AHCYL1 - Putative adenosylhomocysteinase 2 - human protein (Function)
 
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AHCYL1 »  Putative adenosylhomocysteinase 2   [ EC 3.3.1.1 ]  (AdoHcyase 2)
 
Protein also known as:  S-adenosylhomocysteine hydrolase-like protein 1.
Gene name:  AHCYL1
Family name: Adenosylhomocysteinase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression.  
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  • UniProtKB
GO molecular function 
Not  Adenosylhomocysteinase activitydefinition[GO:0004013]  
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  • RefGenome
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
GO biological process 
mRNA polyadenylationdefinition[GO:0006378] silver  
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  • Ortholog Compara
One-carbon metabolic processdefinition[GO:0006730]  
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  • UniProtKB KW
Positive regulation of sodium ion transportdefinition[GO:0010765]  
1
  • UniProtKB
Protein export from nucleusdefinition[GO:0006611] silver  
1
  • Ortholog Compara
Regulation of anion transportdefinition[GO:0044070] silver  
1
  • Ortholog Compara
Regulation of ion transmembrane transporter activitydefinition[GO:0032412]  
1
  • UniProtKB
Regulation of mRNA 3'-end processingdefinition[GO:0031440] silver  
1
  • Ortholog Compara
S-adenosylmethionine cycledefinition[GO:0033353]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.3.1.1: S-adenosyl-L-homocysteine + H(2)O L-homocysteine + adenosine.  
1
  • UniProtKB
It requires the following cofactor
 NAD(+) : Binds 1 NAD(+) per subunit.  
2
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+10768  
Metabolic pathways  hsa01100+10768  
Note 
Ablation of expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.  
2
  • UniProtKB
 

Keywords

Biological process 
One-carbon metabolism  definition   [KW-0554]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AHCYL1
GenomeRNAi: 10768
PRO: PR:O43865