AHCYL1 - Adenosylhomocysteinase 2 - human protein (Function)
 
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AHCYL1 »  Adenosylhomocysteinase 2   [ EC 3.3.1.1 ]  (AdoHcyase 2)
 
Protein also known as:  S-adenosylhomocysteine hydrolase-like protein 1.
Gene name:  AHCYL1
Family name: Adenosylhomocysteinase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed25237103).  
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  • UniProtKB
GO molecular function 
Not  Adenosylhomocysteinase activitydefinition[GO:0004013]  
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  • RefGenome
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
RNA bindingdefinition[GO:0003723]  
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  • UniProtKB KW
GO biological process 
Angiotensin-activated signaling pathwaydefinition[GO:0038166]  
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  • UniProtKB
Epithelial fluid transportdefinition[GO:0042045] silver  
1
  • Ortholog Compara
mRNA polyadenylationdefinition[GO:0006378]  
1
  • UniProtKB
One-carbon metabolic processdefinition[GO:0006730]  
1
  • UniProtKB KW
Positive regulation of sodium ion transportdefinition[GO:0010765]  
1
  • UniProtKB
Protein export from nucleusdefinition[GO:0006611] silver  
1
  • Ortholog Compara
Regulation of anion transportdefinition[GO:0044070] silver  
1
  • Ortholog Compara
Regulation of ion transmembrane transporter activitydefinition[GO:0032412]  
1
  • UniProtKB
Regulation of mRNA 3'-end processingdefinition[GO:0031440]  
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  • UniProtKB
Response to calcium iondefinition[GO:0051592]  
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  • UniProtKB
S-adenosylmethionine cycledefinition[GO:0033353]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.3.1.1: S-adenosyl-L-homocysteine + H(2)O L-homocysteine + adenosine.  
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  • UniProtKB
It requires the following cofactor
 NAD(+) : Binds 1 NAD(+) per subunit.  
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  • UniProtKB
Pathways 
This protein is involved in the following pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+10768  
Metabolic pathways  hsa01100+10768  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
CLEC7A (Dectin-1) induces NFAT activation  R-HSA-5607763  
DAG and IP3 signaling  R-HSA-1489509  
FCERI mediated Ca+2 mobilization  R-HSA-2871809  
PLC beta mediated events  R-HSA-112043  
Regulation of insulin secretion  R-HSA-422356  
Role of phospholipids in phagocytosis  R-HSA-2029485  
VEGFR2 mediated cell proliferation  R-HSA-5218921  
Note 
Ablation of expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.  
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  • UniProtKB
 

Keywords

Biological process 
One-carbon metabolism  definition   [KW-0554]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AHCYL1
GenomeRNAi: 10768
PRO: PR:O43865