CREB3 - Cyclic AMP-responsive element-binding protein 3 - human protein (Function)
 
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CREB3 »  Cyclic AMP-responsive element-binding protein 3  (CREB-3)
 
Protein also known as:  Transcription factor LZIP-alpha. Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3.
Gene name:  CREB3
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency.  
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  • CuratedUniProtKB
Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3'). Associates with chromatin to the HERPUD1 promoter.  
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  • CuratedUniProtKB
Isoform  Iso 2   Plays a role in the unfolded protein response (UPR).  
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  • CuratedUniProtKB
Isoform  Iso 2   Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration.  
13
  • CuratedUniProtKB
Isoform  Iso 2   May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein.  
13
  • CuratedUniProtKB
Isoform  Iso 2   Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection.  
13
  • CuratedUniProtKB
Isoform  Iso 3   Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6).  
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  • CuratedUniProtKB
Isoform  Iso 3   Decreases the acetylation level of histone H4.  
13
  • CuratedUniProtKB
Isoform  Iso 3   Does not promote the chemotactic activity of leukocyte cells.  
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  • CuratedUniProtKB
GO molecular function 
Isoform  Iso 2   cAMP response element binding protein bindingdefinition[GO:0008140]  
1
  • IDAUniProtKB
Isoform  Iso 2   CCR1 chemokine receptor bindingdefinition[GO:0031726]  
1
  • IDAUniProtKB
Isoform  Iso 2   Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
Isoform  Iso 2   DNA bindingdefinition[GO:0003677]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Isoform  Iso 2   Protein dimerization activitydefinition[GO:0046983]  
1
  • TASUniProtKB
Isoform  Iso 2   Protein homodimerization activitydefinition[GO:0042803]  
2
  • IDAUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitydefinition[GO:0000982]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • IMPNTNU_SB
Isoform  Iso 2   RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
2
  • IDAUniProtKB
Isoform  Iso 2   Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • IDAUniProtKB
GO biological process 
Chemotaxisdefinition[GO:0006935]  
  • IEAUniProtKB KW
Isoform  Iso 2   Cytoplasmic sequestering of transcription factordefinition[GO:0042994]  
1
  • IDAUniProtKB
Isoform  Iso 2   Establishment of viral latencydefinition[GO:0019043]  
1
  • IDAUniProtKB
Isoform  Iso 2 but not isoform  Iso 3   Induction of positive chemotaxisdefinition[GO:0050930]  
2
  • IDAUniProtKB
Isoform  Iso 2   Negative regulation of cell cycledefinition[GO:0045786]  
1
  • NASUniProtKB
Isoform  Iso 3 but not isoform  Iso 2   Negative regulation of ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:2000326]  
1
  • IDAUniProtKB
Isoform  Iso 2   Positive regulation of calcium ion transportdefinition[GO:0051928]  
1
  • IMPUniProtKB
Isoform  Iso 2   Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPUniProtKB
Isoform  Iso 3   Positive regulation of deacetylase activitydefinition[GO:0090045]  
1
  • IDAUniProtKB
Isoform  Iso 2   Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • IDAUniProtKB
Positive regulation of monocyte chemotaxisdefinition[GO:0090026]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
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  • IDAUniProtKB
  • IMPNTNU_SB
Isoform  Iso 2   Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responsedefinition[GO:0006990]  
2
  • IDAUniProtKB
Isoform  Iso 2   Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Isoform  Iso 2   Regulation of cell growthdefinition[GO:0001558]  
1
  • IDAUniProtKB
Isoform  Iso 2   Regulation of cell proliferationdefinition[GO:0042127]  
1
  • IMPUniProtKB
Isoform  Iso 2   Release from viral latencydefinition[GO:0019046]  
2
  • IDAUniProtKB
Isoform  Iso 2   Response to endoplasmic reticulum stressdefinition[GO:0034976]  
3
  • IDAUniProtKB
Response to unfolded proteindefinition[GO:0006986]  
  • IEAUniProtKB KW
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAGOC
Isoform  Iso 2   Transcription, DNA-templateddefinition[GO:0006351]  
1
  • IDAUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+10488  
Dopaminergic synapse  hsa04728+10488  
Huntington's disease  hsa05016+10488  
Melanogenesis  hsa04916+10488  
Prostate cancer  hsa05215+10488  
Vasopressin-regulated water reabsorption  hsa04962+10488  
Caution 
All experiments concerning the proteolytic cleavage are done with isoform 2.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]