XPNPEP2 - Xaa-Pro aminopeptidase 2 - human protein (Function)
 
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XPNPEP2 »  Xaa-Pro aminopeptidase 2   [ EC 3.4.11.9 ]
 
Protein also known as:  Membrane-bound aminopeptidase P (mAmP).
Gene name:  XPNPEP2
Family name: Peptidase M24B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin.  
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metallopeptidase activitydefinition[GO:0008237]  
  • IEAUniProtKB KW
GO biological process 
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.11.9: Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 manganese ions per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein digestion and absorption  hsa04974+7512  
 

Keywords

Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XPNPEP2
GenomeRNAi: 7512
PRO: PR:O43895