AIRE - Autoimmune regulator - human protein (Function)
 
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Protein
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AIRE »  Autoimmune regulator
 
Protein also known as:  Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein (APECED protein).
Gene name:  AIRE
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 4
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
Histone bindingdefinition[GO:0042393]  
2
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
Translation regulator activitydefinition[GO:0045182] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Humoral immune responsedefinition[GO:0006959] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Primary immunodeficiency  hsa05340+326  
Ubiquitin mediated proteolysis  hsa04120+326  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Autoimmune_regulator
GenomeRNAi: 326
PRO: PR:O43918