KALRN - Kalirin - human protein (Function)
 
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Protein
Gene
References

 
KALRN »  Kalirin   [ EC 2.7.11.1 ]
 
Protein also known as:  Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain.
Gene name:  KALRN
Entry whose protein(s) existence is based on evidence at protein level
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1 90 6
GENE REF ISO

Function

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Overview 
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Isoform  Iso 2   Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB KW
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
1
  • InterPro 2 GO
GO biological process 
Intracellular signal transductiondefinition[GO:0035556]  
1
  • Ortholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • Ortholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
3
  • GOC
  • InterPro 2 GO
  • UniProtKB KW
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Regulation of Rho protein signal transductiondefinition[GO:0035023] silver  
1
  • InterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Vesicle-mediated transportdefinition[GO:0016192]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
EPHB-mediated forward signaling  R-HSA-3928662  
G alpha (12/13) signalling events  R-HSA-416482  
G alpha (q) signalling events  R-HSA-416476  
MAPK6/MAPK4 signaling  R-HSA-5687128  
NRAGE signals death through JNK  R-HSA-193648  
Rho GTPase cycle  R-HSA-194840  
Note 
Called DUO because the encoded protein is closely related to but shorter than TRIO.  
1
  • UniProtKB
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Kalirin
GenomeRNAi: 8997
PRO: PR:O60229