KALRN - Kalirin - human protein (Function)
 
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KALRN »  Kalirin   [ EC 2.7.11.1 ]
 
Protein also known as:  Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain.
Gene name:  KALRN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • TASPINC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Isoform  Iso 2   Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Intracellular signal transductiondefinition[GO:0035556]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
  • ISSOrtholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • TASGOC
Positive regulation of Rho GTPase activitydefinition[GO:0032321]  
  • IEAInterPro 2 GO
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Vesicle-mediated transportdefinition[GO:0016192]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
G alpha (q) signalling events  REACT_18283  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
Note 
Called DUO because the encoded protein is closely related to but shorter than TRIO.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Kalirin
GenomeRNAi: 8997
PRO: PR:O60229