BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - human protein (Function)
 
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BNIP3L »  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
 
Protein also known as:  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A.
Gene name:  BNIP3L
Family name: NIP3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

 show evidences
Overview 
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family  1.A.20.1.2  
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
Lamin bindingdefinition[GO:0005521]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
GO biological process 
Defense response to virusdefinition[GO:0051607]  
1
  • IDAUniProtKB
Mitochondrial outer membrane permeabilizationdefinition[GO:0097345] silver  
  • IBARefGenome
Mitochondrial protein catabolic processdefinition[GO:0035694]  
1
  • IMPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BNIP3L
GenomeRNAi: 665
PRO: PR:O60238