ADGRB2 - Adhesion G protein-coupled receptor B2 - human protein (Function)
 
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ADGRB2 »  Adhesion G protein-coupled receptor B2
 
Protein also known as:  Brain-specific angiogenesis inhibitor 2.
Gene name:  ADGRB2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway (PubMed20367554). Might be involved in angiogenesis inhibition (By similarity).  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.6.6  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • UniProtKB KW
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
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  • InterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
1
  • InterPro 2 GO
Peripheral nervous system developmentdefinition[GO:0007422] silver  
1
  • Ortholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965] silver  
1
  • Ortholog Compara
Enzymatic activity 
It is regulated in the following manner
Displays increased activity following removal of N-terminal regions (mimicking the situation after proteolytic cleavage in the GPS domain and N-terminal fragment release).  
2
  • UniProtKB
 
More information is available from:
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links