ADGRB3 - Adhesion G protein-coupled receptor B3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
ADGRB3 »  Adhesion G protein-coupled receptor B3
 
Protein also known as:  Brain-specific angiogenesis inhibitor 3.
Gene name:  ADGRB3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 74 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed24567399).  
3
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • UniProtKB KW
GTPase activator activitydefinition[GO:0005096]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
1
  • InterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Myoblast fusiondefinition[GO:0007520]  
1
  • UniProtKB
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
1
  • InterPro 2 GO
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • Ortholog Curator
Positive regulation of synapse assemblydefinition[GO:0051965] silver  
1
  • Ortholog Compara
Regulation of dendrite morphogenesisdefinition[GO:0048814]  
1
  • Ortholog Curator
Enzymatic activity 
 
More information is available from:
Note 
Autoproteolysis appears to be cell specific, does not readily undergo proteolytic cleavage in HEK293T cells.  
2
  • UniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links