GNG7 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 - human protein (Function)
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GNG7 »  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene name:  GNG7
Family name: G protein gamma
Entry whose protein(s) existence is based on evidence at protein level
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Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).  
  • UniProtKB
GO molecular function 
Signal transducer activitydefinition[GO:0004871] silver  
  • Ortholog Compara
GO biological process 
Behavioral fear responsedefinition[GO:0001662] silver  
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
  • InterPro 2 GO
Locomotory behaviordefinition[GO:0007626] silver  
  • Ortholog Compara
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168] silver  
  • Ortholog Compara
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
  • PINC
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2788  
Cholinergic synapse  hsa04725+2788  
Dopaminergic synapse  hsa04728+2788  
GABAergic synapse  hsa04727+2788  
Glutamatergic synapse  hsa04724+2788  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  R-HSA-1296041  
ADP signalling through P2Y purinoceptor 1  R-HSA-418592  
ADP signalling through P2Y purinoceptor 12  R-HSA-392170  
Adrenaline,noradrenaline inhibits insulin secretion  R-HSA-400042  
Ca2+ pathway  R-HSA-4086398  
G alpha (12/13) signalling events  R-HSA-416482  
G alpha (i) signalling events  R-HSA-418594  
G alpha (q) signalling events  R-HSA-416476  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
G beta:gamma signalling through PLC beta  R-HSA-418217  
G-protein activation  R-HSA-202040  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Glucagon-type ligand receptors  R-HSA-420092  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  R-HSA-997272  
Presynaptic function of Kainate receptors  R-HSA-500657  
Prostacyclin signalling through prostacyclin receptor  R-HSA-392851  
Thrombin signalling through proteinase activated receptors (PARs)  R-HSA-456926  
Thromboxane signalling through TP receptor  R-HSA-428930  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  


Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: GNG7
GenomeRNAi: 2788
PRO: PR:O60262