GNG7 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 - human protein (Function)
 
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GNG7 »  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
 
Gene name:  GNG7
Family name: G protein gamma
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAOrtholog Compara
GO biological process 
Behavioral fear responsedefinition[GO:0001662] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
  • IEAInterPro 2 GO
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168] silver  
  • IEAOrtholog Compara
Regulation of adenylate cyclase activitydefinition[GO:0045761] silver  
  • IEAOrtholog Compara
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2788  
Cholinergic synapse  hsa04725+2788  
Dopaminergic synapse  hsa04728+2788  
GABAergic synapse  hsa04727+2788  
Glutamatergic synapse  hsa04724+2788  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNG7
GenomeRNAi: 2788
PRO: PR:O60262