GNG7 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 - human protein (Function)
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GNG7 »  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene name:  GNG7
Family name: G protein gamma
Entry whose protein(s) existence is based on evidence at protein level
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Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).  
  • UniProtKB
GO molecular function 
Signal transducer activitydefinition[GO:0004871] silver  
  • Ortholog Compara
GO biological process 
Behavioral fear responsedefinition[GO:0001662] silver  
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
  • InterPro 2 GO
Locomotory behaviordefinition[GO:0007626] silver  
  • Ortholog Compara
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168] silver  
  • Ortholog Compara
Regulation of adenylate cyclase activitydefinition[GO:0045761] silver  
  • Ortholog Compara
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
  • PINC
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2788  
Cholinergic synapse  hsa04725+2788  
Dopaminergic synapse  hsa04728+2788  
GABAergic synapse  hsa04727+2788  
Glutamatergic synapse  hsa04724+2788  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
ADP signalling through P2Y purinoceptor 1  REACT_19140  
ADP signalling through P2Y purinoceptor 12  REACT_20653  
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
Ca2+ pathway  REACT_263982  
G alpha (12/13) signalling events  REACT_18407  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
G beta:gamma signalling through PI3Kgamma  REACT_19290  
G beta:gamma signalling through PLC beta  REACT_19145  
G-protein activation  REACT_15457  
Glucagon signaling in metabolic regulation  REACT_1665  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Glucagon-type ligand receptors  REACT_18377  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
Presynaptic function of Kainate receptors  REACT_21254  
Prostacyclin signalling through prostacyclin receptor  REACT_23946  
Thrombin signalling through proteinase activated receptors (PARs)  REACT_21384  
Thromboxane signalling through TP receptor  REACT_20647  
Vasopressin regulates renal water homeostasis via Aquaporins  REACT_24023  


Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: GNG7
GenomeRNAi: 2788
PRO: PR:O60262