ADCY3 - Adenylate cyclase type 3 - human protein (Function)
 
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ADCY3 »  Adenylate cyclase type 3   [ EC 4.6.1.1 ]
 
Protein also known as:  Adenylate cyclase, olfactive type.
Gene name:  ADCY3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.  
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  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
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  • PINC
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Calcium- and calmodulin-responsive adenylate cyclase activitydefinition[GO:0008294] silver  
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  • Ortholog Compara
Calmodulin bindingdefinition[GO:0005516]  
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  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
GO biological process 
cAMP biosynthetic processdefinition[GO:0006171] silver  
1
  • Ortholog Compara
Female meiotic divisiondefinition[GO:0007143] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
1
  • Ortholog Compara
Sensory perception of smelldefinition[GO:0007608] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit.  
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  • UniProtKB
It is regulated in the following manner
Activated by calcium/calmodulin.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+109  
Calcium signaling pathway  hsa04020+109  
Chemokine signaling pathway  hsa04062+109  
Cholinergic synapse  hsa04725+109  
GABAergic synapse  hsa04727+109  
Gap junction  hsa04540+109  
Gastric acid secretion  hsa04971+109  
Glutamatergic synapse  hsa04724+109  
GnRH signaling pathway  hsa04912+109  
HTLV-I infection  hsa05166+109  
Melanogenesis  hsa04916+109  
Olfactory transduction  hsa04740+109  
Oocyte meiosis  hsa04114+109  
Pancreatic secretion  hsa04972+109  
Progesterone-mediated oocyte maturation  hsa04914+109  
Purine metabolism  hsa00230+109  
Salivary secretion  hsa04970+109  
Vascular smooth muscle contraction  hsa04270+109  
Vasopressin-regulated water reabsorption  hsa04962+109  
Vibrio cholerae infection  hsa05110+109  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
CREB phosphorylation through the activation of Adenylate Cyclase  R-HSA-442720  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
Olfaction  definition   [KW-0552]
Sensory transduction  definition   [KW-0716]
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY3
GenomeRNAi: 109
PRO: PR:O60266