ADCY3 - Adenylate cyclase type 3 - human protein (Function)
 
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Protein
Gene
References

 
ADCY3 »  Adenylate cyclase type 3   [ EC 4.6.1.1 ]
 
Protein also known as:  Adenylate cyclase, olfactive type.
Gene name:  ADCY3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 2
GENE REF ISO

Function

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Overview 
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.  
2
  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
1
  • Ortholog Curator
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Calcium- and calmodulin-responsive adenylate cyclase activitydefinition[GO:0008294] silver  
1
  • Ortholog Compara
Calmodulin bindingdefinition[GO:0005516]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
GO biological process 
Acrosome reactiondefinition[GO:0007340]  
1
  • Ortholog Curator
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • Ortholog Curator
cAMP biosynthetic processdefinition[GO:0006171]  
2
  • Ortholog Curator
  • RefGenome
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • RefGenome
Cellular response to forskolindefinition[GO:1904322]  
1
  • Ortholog Curator
Female meiotic divisiondefinition[GO:0007143] silver  
1
  • Ortholog Compara
Olfactory learningdefinition[GO:0008355]  
1
  • Ortholog Curator
Sensory perception of smelldefinition[GO:0007608]  
1
  • Ortholog Curator
Single fertilizationdefinition[GO:0007338]  
1
  • Ortholog Curator
Sperm motilitydefinition[GO:0030317]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).  
2
  • UniProtKB
It is regulated in the following manner
Activated by forskolin. After forskolin treatment, activity is further increased by calcium/calmodulin. In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+109  
Calcium signaling pathway  hsa04020+109  
Chemokine signaling pathway  hsa04062+109  
Cholinergic synapse  hsa04725+109  
GABAergic synapse  hsa04727+109  
Gap junction  hsa04540+109  
Gastric acid secretion  hsa04971+109  
Glutamatergic synapse  hsa04724+109  
GnRH signaling pathway  hsa04912+109  
HTLV-I infection  hsa05166+109  
Melanogenesis  hsa04916+109  
Olfactory transduction  hsa04740+109  
Oocyte meiosis  hsa04114+109  
Pancreatic secretion  hsa04972+109  
Progesterone-mediated oocyte maturation  hsa04914+109  
Purine metabolism  hsa00230+109  
Salivary secretion  hsa04970+109  
Vascular smooth muscle contraction  hsa04270+109  
Vasopressin-regulated water reabsorption  hsa04962+109  
Vibrio cholerae infection  hsa05110+109  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
CREB phosphorylation through the activation of Adenylate Cyclase  R-HSA-442720  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
Olfaction  definition   [KW-0552]
Sensory transduction  definition   [KW-0716]
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY3
GenomeRNAi: 109
PRO: PR:O60266