SPAG9 - C-Jun-amino-terminal kinase-interacting protein 4 - human protein (Function)
 
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Protein
Gene
References

 
SPAG9 »  C-Jun-amino-terminal kinase-interacting protein 4  (JIP-4)
 
Protein also known as:  Mitogen-activated protein kinase 8-interacting protein 4.
Gene name:  SPAG9
Family name: JIP scaffold
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.  
2
  • UniProtKB
Isoform  Iso 5   May play a role in spermatozoa-egg-interaction.  
3
  • UniProtKB
GO molecular function 
JUN kinase bindingdefinition[GO:0008432]  
1
  • RefGenome
Kinesin bindingdefinition[GO:0019894]  
1
  • RefGenome
MAP-kinase scaffold activitydefinition[GO:0005078]  
1
  • RefGenome
Mitogen-activated protein kinase p38 bindingdefinition[GO:0048273] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • RefGenome
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • RefGenome
Negative regulation of protein homodimerization activitydefinition[GO:0090074] silver  
1
  • Ortholog Compara
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • Ortholog Compara
Retrograde transport, endosome to Golgidefinition[GO:0042147]  
1
  • MGI
Spermatogenesisdefinition[GO:0007283]  
1
  • PINC
Striated muscle cell differentiationdefinition[GO:0051146] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
CDO in myogenesis  REACT_21402  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SPAG9
GenomeRNAi: 9043
PRO: PR:O60271