NUAK1 - NUAK family SNF1-like kinase 1 - human protein (Function)
 
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NUAK1 »  NUAK family SNF1-like kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  AMPK-related protein kinase 5 (ARK5).
Gene name:  NUAK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed25329316).  
9
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
P53 bindingdefinition[GO:0002039]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
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  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
3
  • UniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
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Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB KW
Cellular response to glucose starvationdefinition[GO:0042149]  
1
  • RefGenome
Negative regulation of TOR signalingdefinition[GO:0032007]  
1
  • RefGenome
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • UniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • UniProtKB
Regulation of cellular senescencedefinition[GO:2000772]  
1
  • UniProtKB
Regulation of myosin-light-chain-phosphatase activitydefinition[GO:0035507]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure.  
2
  • UniProtKB
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
DNA damage  definition   [KW-0227]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NUAK1
GenomeRNAi: 9891
PRO: PR:O60285
Chemistry
GuidetoPHARMACOLOGY: 2129