NUAK1 - NUAK family SNF1-like kinase 1 - human protein (Function)
 
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NUAK1 »  NUAK family SNF1-like kinase 1
 
Gene name:  NUAK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 2
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.  
7
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
P53 bindingdefinition[GO:0002039]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
3
  • IDAUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
  • IEAUniProtKB KW
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • IDAUniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • TASUniProtKB
Regulation of cellular senescencedefinition[GO:2000772]  
1
  • IDAUniProtKB
Regulation of myosin-light-chain-phosphatase activitydefinition[GO:0035507]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
DNA damage  definition   [KW-0227]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NUAK1
GenomeRNAi: 9891
PRO: PR:O60285
Chemistry
GuidetoPHARMACOLOGY: 2129