ZEB2 - Zinc finger E-box-binding homeobox 2 - human protein (Function)
 
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ZEB2 »  Zinc finger E-box-binding homeobox 2
 
Protein also known as:  Zinc finger homeobox protein 1b.
Gene name:  ZEB2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphatase regulator activitydefinition[GO:0019208]  
1
  • NASUniProtKB
R-SMAD bindingdefinition[GO:0070412] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell proliferation in forebraindefinition[GO:0021846] silver  
  • IEAOrtholog Compara
Developmental pigmentationdefinition[GO:0048066]  
1
  • ISSBHF-UCL
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Melanocyte migrationdefinition[GO:0097324]  
1
  • ISSBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
Nervous system developmentdefinition[GO:0007399]  
1
  • NASUniProtKB
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IEAOrtholog Compara
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
  • IEAOrtholog Compara
Positive regulation of melanin biosynthetic processdefinition[GO:0048023]  
1
  • ICBHF-UCL
Positive regulation of melanocyte differentiationdefinition[GO:0045636]  
1
  • ISSBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177] silver  
  • IEAOrtholog Compara
Regulation of melanosome organizationdefinition[GO:1903056]  
1
  • ISSBHF-UCL
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ZEB2
GenomeRNAi: 9839
PRO: PR:O60315