ECE2 - Endothelin-converting enzyme 2 - human protein (Function)
 
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ECE2 »  Endothelin-converting enzyme 2  (ECE-2)
 
Gene name:  ECE2
Family names: In the N-terminal section Methyltransferase
In the C-terminal section Peptidase M13
Entry whose protein(s) existence is based on evidence at protein level
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1 31 5
GENE REF ISO

Function

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Overview 
Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • IDAUniProtKB
Methyltransferase activitydefinition[GO:0008168]  
  • IEAUniProtKB KW
GO biological process 
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Cardioblast differentiationdefinition[GO:0010002]  
  • ISSOrtholog Curator
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASUniProtKB
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Methylationdefinition[GO:0032259]  
  • IEAUniProtKB KW
Peptide hormone processingdefinition[GO:0016486]  
1
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.71: Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 27.4 uM for bradykinin
KM 1.4 uM for peptide E
KM 48.4 uM for dynorphin B
KM 0.4 uM for big ET-1
Dependence
pH Optimum pH is 5.0-5.5. Inactive at neutral pH.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Methyltransferase  definition   [KW-0489]
Protease  definition   [KW-0645]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O60344
Other
GenomeRNAi: 9718
PRO: PR:O60344