FZD6 - Frizzled-6 - human protein (Function)
 
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Gene
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FZD6 »  Frizzled-6  (Fz-6)
 
Gene name:  FZD6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 2
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).  
2
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
Wnt-activated receptor activitydefinition[GO:0042813]  
1
  • BHF-UCL
Wnt-protein bindingdefinition[GO:0017147]  
2
  • BHF-UCL
  • RefGenome
GO biological process 
Cell proliferation in midbraindefinition[GO:0033278] silver  
1
  • Ortholog Compara
Embryonic nail plate morphogenesisdefinition[GO:0035880] silver  
1
  • Ortholog Compara
Establishment of planar polaritydefinition[GO:0001736] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Hair follicle developmentdefinition[GO:0001942] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • BHF-UCL
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • BHF-UCL
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Non-canonical Wnt signaling pathwaydefinition[GO:0035567]  
1
  • BHF-UCL
Platelet activationdefinition[GO:0030168] silver  
1
  • Ortholog Compara
Wnt signaling pathway, planar cell polarity pathwaydefinition[GO:0060071] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8323  
HTLV-I infection  hsa05166+8323  
Melanogenesis  hsa04916+8323  
Pathways in cancer  hsa05200+8323  
Wnt signaling pathway  hsa04310+8323  
According to Reactome, this protein belongs to the following pathways:
Ca2+ pathway  REACT_263982  
Class B/2 (Secretin family receptors)  REACT_18372  
PCP/CE pathway  REACT_264199  
regulation of FZD by ubiquitination  REACT_264580  
RNF mutants show enhanced WNT signaling and proliferation  REACT_264378  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FZD6
GenomeRNAi: 8323
PRO: PR:O60353
Chemistry
GuidetoPHARMACOLOGY: 234