CACNG3 - Voltage-dependent calcium channel gamma-3 subunit - human protein (Function)
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CACNG3 »  Voltage-dependent calcium channel gamma-3 subunit
Protein also known as:  Neuronal voltage-gated calcium channel gamma-3 subunit.
Gene name:  CACNG3
Family name: PMP-22/EMP/MP20 » CACNG
Entry whose protein(s) existence is based on evidence at protein level
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Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(+) channel auxiliary subunit 1-8 (cca) family  8.A.16.2.2  
GO molecular function 
Voltage-gated calcium channel activitydefinition[GO:0005245]  
  • NASUniProtKB
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • IEAUniProtKB KW
Calcium ion transportdefinition[GO:0006816]  
  • NASUniProtKB
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000311]  
  • ISSOrtholog Curator
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+10368  
Cardiac muscle contraction  hsa04260+10368  
Dilated cardiomyopathy  hsa05414+10368  
Hypertrophic cardiomyopathy (HCM)  hsa05410+10368  
MAPK signaling pathway  hsa04010+10368  
According to Reactome, this protein belongs to the following pathway:
Trafficking of AMPA receptors  REACT_18307  


Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: CACNG3
GenomeRNAi: 10368
PRO: PR:O60359