Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
CuratedUniProtKB
According to TCDB this is a transporter from family:
Ca+ channel auxiliary subunit gamma1-gamma8 (CCAgamma) family 8.A.16.2.2
Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Mayo Clin. Proc. 74, 357-361 (1999)[PubMed:10221464]
OBJECTIVE: To identify human genes encoding neuronal voltage-gated calcium channel gamma subunits corresponding to the gamma subunit recently described in mice with hereditary epilepsy, confirm their expression in adult brain, and determine whether a gamma subunit resides in human chromosomal regions with marker genes linked to convulsions. MATERIAL AND METHODS: Human homologues of a recently described mouse gamma subunit were sought by a computerized search of National Center for Biotechnology Information databases. Sequences of interest were mapped electronically to specific chromosomal regions. The proximity of these chromosomal regions to markers linked to convulsive disorders was determined by a MEDLINE search. Predicted gamma subunit sequences were amplified by polymerase chain reaction from a human adult brain complementary DNA (cDNA) library and were subcloned, and full-length sequences were determined or confirmed. Secondary structure and transmembrane regions were predicted by using the TMpredict program. RESULTS: Two putative isoforms (human gamma-2 and gamma-3 calcium channel subunits) were identified, cloned, and sequenced. They mapped to chromosomes 22 and 16, respectively. A marker very close to the gamma-3 gene gives maximal lod scores for an autosomal dominant syndrome of familial infantile convulsions and paroxysmal choreoathetosis. CONCLUSION: Genomic DNA sequence data already existed in GenBank (partial for gamma-2 and complete for gamma-3) for the two putative neuronal calcium channel gamma subunits that we identified. By cloning both of these molecules from a cerebellar cDNA library, we demonstrated for the first time their expression in human brain. The gamma-3 gene is adjacent to a marker for a convulsive disorder. The convulsive phenotype of gamma channelopathies occurring in mice makes the human gamma subunit genes attractive candidate genes for hereditary convulsive disorders.
Mayo Clin. Proc. 74, 357-361 (1999)[PubMed:10221464]
OBJECTIVE: To identify human genes encoding neuronal voltage-gated calcium channel gamma subunits corresponding to the gamma subunit recently described in mice with hereditary epilepsy, confirm their expression in adult brain, and determine whether a gamma subunit resides in human chromosomal regions with marker genes linked to convulsions. MATERIAL AND METHODS: Human homologues of a recently described mouse gamma subunit were sought by a computerized search of National Center for Biotechnology Information databases. Sequences of interest were mapped electronically to specific chromosomal regions. The proximity of these chromosomal regions to markers linked to convulsive disorders was determined by a MEDLINE search. Predicted gamma subunit sequences were amplified by polymerase chain reaction from a human adult brain complementary DNA (cDNA) library and were subcloned, and full-length sequences were determined or confirmed. Secondary structure and transmembrane regions were predicted by using the TMpredict program. RESULTS: Two putative isoforms (human gamma-2 and gamma-3 calcium channel subunits) were identified, cloned, and sequenced. They mapped to chromosomes 22 and 16, respectively. A marker very close to the gamma-3 gene gives maximal lod scores for an autosomal dominant syndrome of familial infantile convulsions and paroxysmal choreoathetosis. CONCLUSION: Genomic DNA sequence data already existed in GenBank (partial for gamma-2 and complete for gamma-3) for the two putative neuronal calcium channel gamma subunits that we identified. By cloning both of these molecules from a cerebellar cDNA library, we demonstrated for the first time their expression in human brain. The gamma-3 gene is adjacent to a marker for a convulsive disorder. The convulsive phenotype of gamma channelopathies occurring in mice makes the human gamma subunit genes attractive candidate genes for hereditary convulsive disorders.
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000311]
Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity.
ISSOrtholog Curator
Pathways
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412+10368
Protein involved in the transport of calcium ions. Calcium is essential for a variety of bodily functions, such as neurotransmission, muscle contraction and proper heart function.
Protein involved in the transport of ions. Such proteins are usually transmembrane and mediate a movement of ions across cell membranes. Transport may be passive (facilitated diffusion; down the electrochemical gradient), or active (against the electrochemical gradient). Active transport requires energy which may come from light, oxidation reactions, ATP hydrolysis, or cotransport of other ions or molecules.
Protein involved in the transport of a molecule (metabolite, protein, etc), a ion or an electron across cell membranes, inside the cell or in a tissue fluid.
Cell membrane glycoprotein forming a channel in a biological membrane selectively permeable to calcium ions. Calcium is essential for a variety of bodily functions, such as neurotransmission, muscle contraction and proper heart function.
Protein which is part of a transmembrane protein complex that forms a hydrophilic channel across the lipid bilayer through which specific inorganic ions can diffuse down their electrochemical gradients. The channels are usually gated and only open in response to a specific stimulus, such as a change in membrane potential (voltage-gated) or the binding of a ligand (ligand-gated channel).
Protein which is a component of a voltage-gated channel. Voltage-gated ion channels are responsible for the electrical activity in a variety of cell types. They probably exist in all life forms.
A reference proteome is a set of protein sequences derived from a complete proteome which constitutes a defined standard for a particular user community. Reference proteomes are manually defined according to a number of criteria. They cover the proteomes of well- studied model organisms and other proteomes of interest for biomedical and biotechnological research. Reference proteomes have been selected to provide broad coverage of the tree of life, and constitute a representative cross-section of the taxonomic diversity to be found within UniProtKB.
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