ATP8B3 - Phospholipid-transporting ATPase IK - human protein (Function)
 
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ATP8B3 »  Phospholipid-transporting ATPase IK   [ EC 3.6.3.1 ]
 
Protein also known as:  ATPase class I type 8B member 3.
Gene name:  ATP8B3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 3
GENE REF ISO

Function

 show evidences
Overview 
P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887]  
1
  • RCAUniProtKB
Cation-transporting ATPase activitydefinition[GO:0019829] silver  
  • IEAInterPro 2 GO
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Phospholipid-translocating ATPase activitydefinition[GO:0004012]  
  • IEAEC 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • RCAGOC
Binding of sperm to zona pellucidadefinition[GO:0007339] silver  
  • IEAOrtholog Compara
Cation transportdefinition[GO:0006812] silver  
  • IEAInterPro 2 GO
Phospholipid translocationdefinition[GO:0045332] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.1: ATP + H(2)O + phospholipid(Side 1) ADP + phosphate + phospholipid(Side 2).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
Note 
Association with flippase complex beta subunits TMEM30A and TMEM30A has not been detected, neither did their coexpression change the localization in ER (PubMed20947505).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP8B3
GenomeRNAi: 148229
PRO: PR:O60423