FADS1 - Fatty acid desaturase 1 - human protein (Function)
 
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Protein
Gene
References

 
FADS1 »  Fatty acid desaturase 1   [ EC 1.14.19.- ]
 
Protein also known as:  Delta(5) fatty acid desaturase (D5D).
Gene name:  FADS1
Family name: Fatty acid desaturase
Entry whose protein(s) existence is based on evidence at protein level
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1 60 2
GENE REF ISO

Function

 show evidences
Overview 
Isoform  Iso 1   Is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.  
2
  • CuratedUniProtKB
Isoform  Iso 2   Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
C-5 sterol desaturase activitydefinition[GO:0000248]  
1
  • TASPINC
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Oxidoreductase activitydefinition[GO:0016491]  
1
  • IDAUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Arachidonic acid metabolic processdefinition[GO:0019369] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • NASUniProtKB
Cellular response to starvationdefinition[GO:0009267]  
1
  • IDAUniProtKB
Icosanoid biosynthetic processdefinition[GO:0046456]  
1
  • TASUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Phospholipid biosynthetic processdefinition[GO:0008654]  
1
  • TASUniProtKB
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • NASUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to sucrosedefinition[GO:0009744] silver  
  • IEAOrtholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Unsaturated fatty acid biosynthetic processdefinition[GO:0006636]  
1
  • IDAUniProtKB
  • IEAUniPathway
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Biosynthesis of unsaturated fatty acids  hsa01040+3992  
According to Reactome, this protein belongs to the following pathways:
alpha-linolenic acid (ALA) metabolism  REACT_121147  
Linoleic acid (LA) metabolism  REACT_121100  
PPARA activates gene expression  REACT_116145  
 
More information is available from:
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FADS1
GenomeRNAi: 3992
PRO: PR:O60427