NRP2 - Neuropilin-2 - human protein (Function)
 
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NRP2 »  Neuropilin-2
 
Protein also known as:  Vascular endothelial cell growth factor 165 receptor 2.
Gene name:  NRP2
Family name: Neuropilin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.  
  • CuratedUniProtKB
GO molecular function 
Cytokine bindingdefinition[GO:0019955]  
1
  • NASBHF-UCL
Growth factor bindingdefinition[GO:0019838]  
1
  • TASBHF-UCL
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Semaphorin receptor activitydefinition[GO:0017154]  
2
  • NASBHF-UCL
  • NASUniProtKB
Vascular endothelial growth factor-activated receptor activitydefinition[GO:0005021]  
2
  • NASBHF-UCL
  • NASUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • NASUniProtKB
Axon extension involved in axon guidancedefinition[GO:0048846]  
  • ISSOrtholog Curator
Axon guidancedefinition[GO:0007411]  
1
  • NASBHF-UCL
Cell adhesiondefinition[GO:0007155]  
1
  • NASUniProtKB
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Negative chemotaxisdefinition[GO:0050919] silver  
  • IEAOrtholog Compara
Nerve developmentdefinition[GO:0021675]  
  • ISSOrtholog Curator
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • TASBHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • TASBHF-UCL
Semaphorin-plexin signaling pathway involved in neuron projection guidancedefinition[GO:1902285]  
  • ISSOrtholog Curator
Sympathetic ganglion developmentdefinition[GO:0061549]  
  • ISSOrtholog Curator
Sympathetic neuron projection extensiondefinition[GO:0097490]  
  • ISSOrtholog Curator
Sympathetic neuron projection guidancedefinition[GO:0097491]  
  • ISSOrtholog Curator
Vascular endothelial growth factor signaling pathwaydefinition[GO:0038084] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathways:
Neurophilin interactions with VEGF and VEGFR  REACT_12473  
NrCAM interactions  REACT_22329  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NRP2
GenomeRNAi: 8828
PRO: PR:O60462